Document Detail


Activation of the human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin.
MedLine Citation:
PMID:  22300345     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract The aim of the present study was to determine whether dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one inhibit the activation of human leukemic LAD2 mast cells induced by compound 48/80 or the calcium ionophore A23187. LAD2 cells were preincubated in the presence of test drugs and then challenged with the secretagogues. The present study provides the first evidence in favour of the view that dehydroleucodine and xanthatin inhibit the degranulation of LAD2 cells, acting thus as human mast cell stabilizers. These molecules could be effective in the treatment of human diseases associated with inappropriate mast cell activation.
Authors:
Mariano E Vera; Fabio A Persia; María L Mariani; María I Rudolph; Teresa H Fogal; Juan P Ceñal; Laura S Favier; Carlos E Tonn; Alicia B Penissi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-3
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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