| Activation-flow coupling differentiates between vascular and Alzheimer type of dementia. | |
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MedLine Citation:
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PMID: 17321550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activation-flow coupling describes a mechanism, which adapts local cerebral blood flow in accordance with the underlying neuronal activity. It was suggested that the mechanism helps in differentiation between Alzheimer and vascular type of dementia. We combined EEG and Doppler techniques and assessed integrity of the activation-flow coupling in the occipital cortex utilizing a visual stimulation task. Alzheimer patients (MMSE: 18+/-8 points, DemTect 5+/-4 points) without signs of vascular lesions on a MRI scan and vascular demented patients (MMSE: 20+/-6 points, DemTect 6+/-3 points; MRI Fazekas score 7+/-3 points) were compared with data from an age-matched control group. Evoked flow velocity responses in the posterior cerebral artery were analysed according to a control system model specifying the parameters gain, attenuation, natural frequency and rate time. Evoked potentials were analysed for the N(75)-P(100) amplitude difference. Vascular demented patients exhibited a significant decreased gain parameter and increased attenuation parameter indicating severe cerebrovascular dysfunction. Also, the potential amplitudes were significantly decreased indicating neuronal damage due to the vascular disease process. Alzheimer patients did not differ in parameters as compared to the control group supporting other reports of intact occipital function at this stage of disease. Simultaneous assessment of electrical as well as vascular integrity might help in differentiating the most frequent forms of dementia. |
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Authors:
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Bernhard Rosengarten; Sönke Paulsen; Sandor Molnar; Reiner Kaschel; Bernd Gallhofer; Manfred Kaps |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-23 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 257 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-11 Completed Date: 2007-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 149-54 Citation Subset: IM |
Affiliation:
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Department of Neurology, Justus-Liebig University of Giessen, Am Steg 14, 35392 Giessen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / metabolism, physiopathology, ultrasonography* Cerebrovascular Circulation / physiology* Dementia, Vascular / metabolism, physiopathology, ultrasonography* Diagnosis, Differential Electroencephalography / methods Energy Metabolism / physiology Evoked Potentials, Visual / physiology Female Humans Male Middle Aged Nerve Degeneration / metabolism, physiopathology, ultrasonography Neuropsychological Tests Occipital Lobe / metabolism, physiopathology, ultrasonography* Photic Stimulation Posterior Cerebral Artery / physiopathology, ultrasonography* Predictive Value of Tests Ultrasonography, Doppler, Transcranial / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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