| Activation of fanconi anemia pathway in cells with re-replicated DNA. | |
| | |
MedLine Citation:
|
PMID: 17102625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To maintain genome stability, the cell has to limit initiation of DNA replication to once per cell cycle. Loss of this control leads to DNA rereplication with repeated firing of replication origins in the same cell cycle. Rereplication generates both ssDNA and double strand breaks, as well as activation of the DNA damage checkpoint. In rereplicated cells, activation of the checkpoint is critical to arrest cells in G(2) resulting in accumulation of cells with rereplicated DNA. Abrogation of this checkpoint suppresses the progressive accumulation of cells with excess DNA and causes apoptosis. Recently, the Fanconi Anemia pathway was reported to be activated in rereplicating cells. Interestingly, FA core complexes but not FANCD2, is required for checkpoint activation in rereplicated cells, suggesting that the pathway to checkpoint activation requires the ubiquitination of substrates other than FANCD2. In addition, FANCD2 is required for recruitment of Rad51 to foci in rereplicated cells, so that the repair pathways activated after small degrees of rereplication are expected to be compromised in cells with mutations in the FA pathway. |
| | |
Authors:
|
Wenge Zhu; Anindya Dutta |
Related Documents
:
|
21541505 - Spontaneously transformed rat pancreatic epithelial oval cells give rise to ductal type... 11237575 - Resonance in periodic chemotherapy: a case study of acute myelogenous leukemia. 402125 - Synchronization of anacystis nidulans. oxygen evolution during the cell cycle. 2000225 - The phosphorylation state of the retinoblastoma (rb) protein in g0/g1 is dependent on g... 17292885 - Regulation of multiple cell cycle events by cdc14 homologues in vertebrates. 7779865 - The effects of terbium on the accumulation of cisplatin in human ovarian cancer cells. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-10-16 |
Journal Detail:
|
Title: Cell cycle (Georgetown, Tex.) Volume: 5 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-11-19 Completed Date: 2007-01-03 Revised Date: 2011-05-06 |
Medline Journal Info:
|
Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
|
Languages: eng Pagination: 2306-9 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
DNA Damage* DNA Repair DNA Replication* Fanconi Anemia / genetics, metabolism*, pathology Fanconi Anemia Complementation Group D2 Protein / physiology Humans Interphase Mutation Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
|
CA60499/CA/NCI NIH HHS; R01 CA060499-13/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fanconi Anemia Complementation Group D2 Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The mitotic spindle matrix: a fibro-membranous lamin connection.
Next Document: Pax5 maintains cellular identity by repressing gene expression throughout B cell differentiation.