Document Detail

Activation of excitatory amino acid inputs to supraoptic neurons. I. Induced increases in dye-coupling in lactating, but not virgin or male rats.
MedLine Citation:
PMID:  2161699     Owner:  NLM     Status:  MEDLINE    
Mitral cells of the main and accessory olfactory bulbs have been shown to project monosynaptically to the supraoptic nucleus (SON) via the lateral olfactory tract (LOT) which uses excitatory amino acid transmitters. Data collected during characterization of these projections suggested that synaptic activation of SON neurons via LOT stimulation in slices influenced the incidence of dye-coupling. The present study pursued this suggestion using horizontally cut slices from male, virgin female and lactating rats. Neurons were confirmed to be excited by electrical stimulation of the tract, injected with Lucifer yellow, and synaptically activated for 10 min at 10 Hz (n = 92). Another 94 neurons were similarly confirmed and injected, but received no further stimulation. In an additional 8 slices, injected neurons were antidromically activated for 10 min at 10 Hz. Analyses done on 194 injected neurons from the 3 groups showed that synaptic activation resulted in a significant (P less than 0.01) increase in the incidence of coupling only in tissue from lactating rats. This increase was entirely due to larger numbers of cells being coupled dendrodendritically to the injected cells in the stimulated slices. Antidromic activation did not influence coupling. Increased coupling occurred among both oxytocin and vasopressin cell types. This is the first report of increased coupling resulting from synaptic activation in mammalian CNS. Changes seen only in lactating rats may be related to their altered SON ultrastructural morphology (i.e. dendritic bundling). Strong olfactory and vomeronasal input associated with some maternal behaviors may increase neuronal coupling and enhance hormone release in response to other incoming stimuli (e.g. suckling, dehydration).
G I Hatton; Q Z Yang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  513     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-07-16     Completed Date:  1990-07-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  264-9     Citation Subset:  IM    
Neuroscience Program, Michigan State University, East Lansing 48824-1117.
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MeSH Terms
Action Potentials
Amino Acids / physiology*
Central Nervous System / physiology*
Electric Stimulation
Fluorescent Dyes / diagnostic use
Intercellular Junctions / physiology*
Lactation / physiology*
Olfactory Bulb / physiology
Olfactory Pathways / physiology*
Rats, Inbred Strains
Supraoptic Nucleus / physiology*
Synaptic Transmission
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Fluorescent Dyes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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