| Activation-dependent induction of Blimp-1. | |
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MedLine Citation:
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PMID: 18554885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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B lymphocyte induced maturation protein-1 (Blimp-1) mRNA is induced upon antigen-dependent activation of both T and B lymphocytes, in spite of the fact that it plays very different roles in the two lineages. B cells have at least four different mechanisms to repress Blimp-1 and repression is relieved before induction. Only one repressor, Bcl-6, is known in T cells. Activators must also be present to induce Blimp-1 in both T and B cells. Cytokines IL-21, IL-10, and IL-6, activating STAT3, are crucial in B cells along with toll-like receptor (TLR) signals, whereas IL-2 is crucial in T cells. AP-1, NF-kappaB, and IRF4 also activate Blimp-1. |
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Authors:
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Kathryn Calame |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-06-12 |
Journal Detail:
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Title: Current opinion in immunology Volume: 20 ISSN: 0952-7915 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-25 Completed Date: 2008-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 259-64 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. KLC1@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocytes / immunology* Cytokines / physiology Gene Expression Regulation Humans Lymphocyte Activation* Mice Repressor Proteins / biosynthesis, genetics*, metabolism T-Lymphocytes / immunology* Trans-Activators / physiology Transcription Factors / biosynthesis, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Prdm1 protein, mouse; 0/Repressor Proteins; 0/Trans-Activators; 0/Transcription Factors; 138415-26-6/PRDM1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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