Document Detail


Activation-dependent induction of Blimp-1.
MedLine Citation:
PMID:  18554885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
B lymphocyte induced maturation protein-1 (Blimp-1) mRNA is induced upon antigen-dependent activation of both T and B lymphocytes, in spite of the fact that it plays very different roles in the two lineages. B cells have at least four different mechanisms to repress Blimp-1 and repression is relieved before induction. Only one repressor, Bcl-6, is known in T cells. Activators must also be present to induce Blimp-1 in both T and B cells. Cytokines IL-21, IL-10, and IL-6, activating STAT3, are crucial in B cells along with toll-like receptor (TLR) signals, whereas IL-2 is crucial in T cells. AP-1, NF-kappaB, and IRF4 also activate Blimp-1.
Authors:
Kathryn Calame
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-06-12
Journal Detail:
Title:  Current opinion in immunology     Volume:  20     ISSN:  0952-7915     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. KLC1@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / immunology*
Cytokines / physiology
Gene Expression Regulation
Humans
Lymphocyte Activation*
Mice
Repressor Proteins / biosynthesis,  genetics*,  metabolism
T-Lymphocytes / immunology*
Trans-Activators / physiology
Transcription Factors / biosynthesis,  genetics*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Prdm1 protein, mouse; 0/Repressor Proteins; 0/Trans-Activators; 0/Transcription Factors; 138415-26-6/PRDM1 protein, human

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