Document Detail

Activation delay in healed myocardial infarction: a comparison between model and experiment.
MedLine Citation:
PMID:  7485579     Owner:  NLM     Status:  MEDLINE    
Conduction delay in healed myocardial infarction, facilitating reentry, is frequently based on an increased path length the activation has to travel in a matrix of merging and diverging bundles that survive in the infarcted area. Additional delay occurs at sites where bundles bifurcate. The purpose of this study was to investigate conduction delay at sites where bundles bifurcate. A computer model was developed to simulate spread of activation in a two-dimensional sheet of excitable elements. A structure consisting of two isolated bundles merging into a single one was modeled. Extracellular electrograms calculated in the model were comparable to electrograms obtained in a superfused infarcted papillary muscle model. A zone of crowded isochrones or local conduction delay was found at the site where an isolated bundle bifurcated. The position of the isochrones in this area depended on the way activation times were determined. Lines of activation delay were mainly perpendicular to the fiber direction. In conclusion, the results have enabled us to better understand extracellular electrograms at pivoting points and show that activation sequences at a microscopic level can best be constructed on the basis of Laplacian signals.
N Maglaveras; J M De Bakker; F J Van Capelle; C Pappas; M J Janse
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  269     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1441-9     Citation Subset:  IM    
Laboratory of Medical Informatics, Aristotelian University Medical School, Thessaloniki, Macedonia, Greece.
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MeSH Terms
Computer Simulation
Extracellular Space / physiology
Heart Conduction System / physiopathology*
Intracellular Fluid / physiology
Models, Cardiovascular*
Myocardial Infarction / physiopathology*
Neural Conduction*

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