| Activation delay in healed myocardial infarction: a comparison between model and experiment. | |
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MedLine Citation:
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PMID: 7485579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conduction delay in healed myocardial infarction, facilitating reentry, is frequently based on an increased path length the activation has to travel in a matrix of merging and diverging bundles that survive in the infarcted area. Additional delay occurs at sites where bundles bifurcate. The purpose of this study was to investigate conduction delay at sites where bundles bifurcate. A computer model was developed to simulate spread of activation in a two-dimensional sheet of excitable elements. A structure consisting of two isolated bundles merging into a single one was modeled. Extracellular electrograms calculated in the model were comparable to electrograms obtained in a superfused infarcted papillary muscle model. A zone of crowded isochrones or local conduction delay was found at the site where an isolated bundle bifurcated. The position of the isochrones in this area depended on the way activation times were determined. Lines of activation delay were mainly perpendicular to the fiber direction. In conclusion, the results have enabled us to better understand extracellular electrograms at pivoting points and show that activation sequences at a microscopic level can best be constructed on the basis of Laplacian signals. |
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Authors:
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N Maglaveras; J M De Bakker; F J Van Capelle; C Pappas; M J Janse |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 269 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-12-12 Completed Date: 1995-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1441-9 Citation Subset: IM |
Affiliation:
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Laboratory of Medical Informatics, Aristotelian University Medical School, Thessaloniki, Macedonia, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Computer Simulation Electrophysiology Extracellular Space / physiology Heart Conduction System / physiopathology* Humans Intracellular Fluid / physiology Models, Cardiovascular* Myocardial Infarction / physiopathology* Neural Conduction* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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