Document Detail


Activation and cytotoxicity of 5'-deoxy-5-fluorouridine in c-H-ras transformed NIH 3T3 cells.
MedLine Citation:
PMID:  1824924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transformation of NIH 3T3 cells with c-H-ras has been demonstrated to result in significantly increased activation of 5'-deoxy-5-fluorouridine and significantly increased cytotoxicity in vitro as compared to non-transformed NIH 3T3. FUra cytotoxicity appeared to be increased also in vitro upon transformation; the level of significance however was beyond that of accepted significance (0.05 less than P less than 0.01). Furthermore dFUrd proved to be less active in vivo in nude mice bearing v-fos transformed NIH 3T3 cells than in nude mice bearing c-H-ras transformed cells.
Authors:
Y Geng; E Gheuens; E A de Bruijn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  41     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-02-28     Completed Date:  1991-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  301-3     Citation Subset:  IM    
Affiliation:
Laboratory of Cancer Research & Clinical Oncology, University of Antwerp, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotransformation
Cell Survival / drug effects
Cell Transformation, Neoplastic / genetics*,  metabolism
Dose-Response Relationship, Drug
Floxuridine / pharmacology*
Fluorouracil / metabolism
Genes, ras / drug effects*
Mice
Mice, Nude
Structure-Activity Relationship
Transfection
Tumor Cells, Cultured / drug effects
Chemical
Reg. No./Substance:
3094-09-5/doxifluridine; 50-91-9/Floxuridine; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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