| Activation of cyclophosphamide for in vitro testing of cell sensitivity. | |
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MedLine Citation:
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PMID: 7438076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two methods are described for the activation of cyclophosphamide by a liver microsome preparation. These procedures were applicable to an assay in vitro which tests the sensitivity of tumor cells to the drug. Satisfactory results were obtained either by pretreatment of the cyclophosphamide and removal of the microsomes before testing or by the somewhat simpler procedure of mixing drug, microsomes, and test cells for the assay. Microsome treatment of bleomycin gave a smaller increase in activity, and much smaller effects were seen on some other drugs. |
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Authors:
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S Shrivastav; K R Stone; D F Paulson; R A Bonar |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 40 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-02-24 Completed Date: 1981-02-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4443-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / metabolism Biotransformation Cells, Cultured Cyclophosphamide / metabolism* Drug Evaluation, Preclinical / methods Humans Kidney Neoplasms / metabolism Mice Mice, Nude Microsomes, Liver / metabolism* Neoplasms, Experimental / metabolism Urinary Bladder Neoplasms / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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CA14930/CA/NCI NIH HHS; CA15972/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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