Document Detail

Activation of complement by plicatic acid, the chemical compound responsible for asthma due to western red cedar (Thuja plicata).
MedLine Citation:
PMID:  6768786     Owner:  NLM     Status:  MEDLINE    
Plicatic acid, a low-molecular-weight compound responsible for western red cedar (Thuja plicata) asthma was tested for its ability to activate complement and to generate chemotactic activity from pooled normal human serum (NHS). Dose-dependent complement consumption was found as determined by hemolytic assay (CH50). Activation of complement by plicatic acid was also confirmed by the demonstration of conversion of C3 to C3b on immunoelectrophoresis. This activation was completely prevented by pretreating the serum with either edetate (EDTA) or ethylene glycol tetraacetic acid (EGTA), suggesting that complement was activated via the classical pathway. No conversion of factor B was seen in any of the samples. Leukocyte chemotactic activity was also generated when serum was incubated with plicatic acid. The consumption of C3 and CH50 was unimpaired in two samples of serum from patients with severe, untreated hypogammaglobulinemia and thus appears to be immunoglobulin independent. These observations suggest that plicatic acid could activate complement in vivo, thereby inducing an inflammatory response in the airways and contributing to the higher prevalence of industrial chronic bronchitis in exposed subjects. The pathogenetic role of complement activation in red cedar asthma has yet to elucidated.
M Chan-Yeung; P C Giclas; P M Henson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  65     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-07-28     Completed Date:  1980-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-7     Citation Subset:  AIM; IM    
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MeSH Terms
Asthma / chemically induced*
Carboxylic Acids / pharmacology
Chemotaxis, Leukocyte
Complement Activation / drug effects*
Complement C3
Edetic Acid / pharmacology
Egtazic Acid / pharmacology
Naphthols / pharmacology*
Trees / immunology*
Zymosan / pharmacology
Reg. No./Substance:
0/Carboxylic Acids; 0/Complement C3; 0/Lignans; 0/Naphthols; 16462-65-0/plicatic acid; 60-00-4/Edetic Acid; 67-42-5/Egtazic Acid; 9010-72-4/Zymosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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