| Activation of coagulation in bullous pemphigoid and other eosinophil-related inflammatory skin diseases. | |
| | |
MedLine Citation:
|
PMID: 21488867 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Bullous pemphigoid (BP) is a skin disease caused by autoantibodies to hemidesmosomal proteins BP180 and BP230, with eosinophils participating in blister formation. Tissue factor (TF), the initiator of coagulation, is embodied within the eosinophil granules and exposed upon activation. We evaluated the coagulation activation in patients with BP (63), chronic urticaria (CU; 20), atopic dermatitis (AD; 14), cutaneous drug reactions (CDRs; six), psoriasis (20), dermatitis herpetiformis (DH; four) and primary cutaneous T cell lymphoma (CTCL; five), and in 40 healthy controls. Prothrombin fragment F1+2 and d-dimer (coagulation markers) were measured by enzyme-linked immunosorbent assay (ELISA) in all plasma samples and BP blister fluid. Skin TF expression was evaluated immunohistochemically in the patients and 20 controls. F1+2 and d-dimer levels were higher in BP plasma than in control plasma (P = 0·0001 for both), and dramatically high in blister fluid; both correlated positively with disease severity, esinophil counts and anti-BP180 antibodies (P = 0·006-0·0001). Plasma F1+2 and d-dimer levels were higher in the CU, AD and CDR patients than in controls (P = 0·0001 for all), but normal in the psoriasis, DH and CTCL patients. Skin TF was expressed in the BP (P = 0·0001), CU (P = 0·0001), AD (P = 0·001) and CDR patients (P = 0·01), but not in the psoriasis, DH or CTCL patients. Co-localization confocal microscopy studies confirmed eosinophils as the source of TF in 10 BP patients. The coagulation cascade is activated in BP and other eosinophil-mediated skin disorders, but not in non-eosinophil driven conditions. This hypercoagulability may contribute to inflammation, tissue damage and, possibly, thrombotic risk. |
| | |
Authors:
|
A V Marzano; A Tedeschi; E Berti; D Fanoni; C Crosti; M Cugno |
Related Documents
:
|
2344427 - Routine pre-operative electrocardiography. 10969627 - Comparison of clinical, morphological, and prognostic features in hypertrophic cardiomy... 17512787 - Effect of cpap on qt interval dispersion in obstructive sleep apnea patients without hy... 21441397 - Multiorgan gadolinium (gd) deposition and fibrosis in a patient with nephrogenic system... 19614637 - Atrial fibrillation in patients with constrictive pericarditis: the significance of per... 6801027 - Maprotiline and seizures. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-13 |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: - ISSN: 1365-2249 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors; Clinical and Experimental Immunology © 2011 British Society for Immunology. |
Affiliation:
|
Dipartimento di Medicina Interna, Università degli Studi di Milano Unità Operativa di Dermatologia Unità Operativa di Allergologia e Immunologia Clinica, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Università degli Studi di Milano, Milano, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Importance of B cell co-stimulation in CD4(+) T cell differentiation: X-linked agammaglobulinaemia, ...
Next Document: IL-9(+) IL-10(+) T cells link immediate allergic response to late phase reaction.