Document Detail

Activation of coagulation and hyperfibrinolysis in patients with aortic arch atheromatosis (Aortic AA) as a risk factor for cerebral ischemia.
MedLine Citation:
PMID:  15841313     Owner:  NLM     Status:  MEDLINE    
In patients with cerebral ischemia, a frequent finding is atheromatous plaques in the ascending aorta and the aortic arch. Since we were able to demonstrate that patients with atrial fibrillation have an increased coagulatory activity, we wanted to evaluate a potential systemic activation of the coagulatory system in patients with aortic arch atheromatosis (Aortic AA). In 134 consecutive patients, we determined several parameters of the coagulatory and fibrinolytic systems as well as several thrombophilia risk factors and compared the results with 134 age- and sex-matched healthy controls. In 90 of the 134 patients, transesophageal echocardiography showed Aortic AA, and in the remaining 44 patients, there were no aortic findings. The Aortic AA group showed higher concentrations of thrombin-antithrombin (TAT) and plasmin-antiplasmin complexes (PAP). Further division into 4 subgroups of different severity (grade I: no plaques; grade II: plaques 2-5 mm, grade III: plaques > 5 mm, grade IV: mobile plaques), revealed increasing concentrations of fibrinogen, D-dimers and tissue-type plasminogen activator. The grade IV-group displayed the highest values in comparison to all other groups. In conclusion, Aortic AA as such is a risk factor for cerebral ischemia. It causes a systemically detectable activation of coagulation which substantially exceeds the values for controls. This observation is in accordance with our findings in patients with atrial fibrillation.
Hans-Joachim G Siemens; Wladimir Mirau; Sabine Brueckner; Juergen Jahn; Angela Roth-Isigkeit; Sven Gutsche; Rolf Mitusch; Abdolhamid Sheikhzadeh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  93     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-20     Completed Date:  2005-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  690-3     Citation Subset:  IM    
Department of Internal Medicine, University of Luebeck, Wakenitzufer 26, D-23564 Luebeck, Germany.
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MeSH Terms
Aged, 80 and over
Aortic Arch Syndromes / blood,  complications*
Arteriosclerosis / blood,  complications
Biological Markers / blood
Blood Coagulation*
Brain Ischemia / etiology*
Case-Control Studies
Middle Aged
Risk Factors
Severity of Illness Index
Thrombophilia / blood
Reg. No./Substance:
0/Biological Markers

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