Document Detail


Activation of clotting factors XI and IX in patients with acute myocardial infarction.
MedLine Citation:
PMID:  11073857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In acute coronary events, plaque rupture and the subsequent formation of the catalytic tissue factor-factor VIIa complex is considered to initiate coagulation. It is unknown whether clotting factors XI and IX are activated in acute coronary events. Therefore, we prospectively investigated the activation of clotting factors XI and IX as well as activation of the contact system and the common pathway in 50 patients with acute myocardial infarction (AMI), in 50 patients with unstable angina pectoris (UAP), and in 50 patients with stable angina pectoris (SAP). Factor XIa-C1 inhibitor complexes, which reflect acute activation of factor XI, were detected in 24% of the patients with AMI, 8% of the patients with UAP, and 4% of the patients with SAP (P<0.05), whereas factor XIa-alpha(1)-antitrypsin complexes, which reflect chronic activation, were observed equally in all 3 study groups. Factor IX peptide levels were significantly higher in the patients with AMI and UAP compared with the patients with SAP (P<0.01). No differences regarding markers of the common pathway were demonstrated. Fibrinopeptide A levels were elevated in patients with AMI compared with patients with UAP and those with SAP (P<0.01). Factor XIIa- or kallikrein-C1 inhibitor complexes were not increased. In conclusion, this is the first demonstration of the activation of clotting factors XI and IX in patients with acute coronary syndromes. Because these clotting factors are considered to be important for continuous thrombin generation and clot stability, their activation might have clinical and therapeutic consequences.
Authors:
M C Minnema; R J Peters; R de Winter; Y P Lubbers; S Barzegar; K A Bauer; R D Rosenberg; C E Hack; H ten Cate
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  20     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-17     Completed Date:  2000-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2489-93     Citation Subset:  IM    
Affiliation:
Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands. Jasem@wxs.nl
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / blood
Complement C1 Inactivator Proteins / metabolism
Factor IX / metabolism
Factor IXa / metabolism*
Factor XI / metabolism
Factor XIa / metabolism*
Female
Humans
Male
Middle Aged
Myocardial Infarction / blood*
Prospective Studies
Chemical
Reg. No./Substance:
0/Complement C1 Inactivator Proteins; 9001-28-9/Factor IX; 9013-55-2/Factor XI; EC 3.4.21.22/Factor IXa; EC 3.4.21.27/Factor XIa

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