Document Detail

Activation of circulating polymorphonuclear leukocytes in preterm infants with severe idiopathic respiratory distress syndrome.
MedLine Citation:
PMID:  8929866     Owner:  NLM     Status:  MEDLINE    
We have studied activation of circulating polymorphonuclear leukocytes (PMN) in plasma of preterm infants with severe idiopathic respiratory distress syndrome (IRDS group, n = 15) and without IRDS (reference group, n = 15) during the first 5 postnatal days. We have observed lower median PMN counts in the IRDS group than in the reference group from d 2 (1.4 x 10(9)/L versus 4.8 x 10(9)/L in the reference group, p < 0.001) to d 4 to 6 (1.6 x 10(9)/L versus 4.0 x 10(9)/L, p < 0.01). Lower PMN counts in the IRDS infants were accompanied by lower median plasma elastase-alpha1-proteinase inhibitor (PI) concentrations (53.6 ng/mL versus 128.0 ng/mL in the reference group on d 2, p < 0.05). Simultaneously, median elastase-alpha1-PI/PMN ratios of these infants were significantly higher (40.8 ng/10(6) PMN versus 21.8 ng/10(6) PMN on d 2, p < 0.05), indicating activation of circulating PMN. Activation of circulating PMN in the IRDS group is associated with platelet-activating factor (PAF) release and complement activation from within 6 to 12 h of birth but not with release of tumor necrosis factor-alpha. PAF release was represented by significantly reduced inhibiting capacity (58% of normal human plasma, p < 0.01) and complement activation by higher median plasma C3a des-Arg concentrations (1680 ng/mL versus 325 ng/mL in the reference group, p < 0.001). We conclude that circulating PMN are activated in preterm infants with severe IRDS, which might be caused by systemic PAF release and complement activation. This activation process may play a role in the pathogenesis of the IRDS by influx of activated PMN into the lungs.
F Brus; W van Oeveren; A Okken; S O Bambang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  39     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1997-02-06     Completed Date:  1997-02-06     Revised Date:  2013-08-23    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  456-63     Citation Subset:  IM    
Beatrix Childrens Hospital, Division of Neonatology, University Hospital Groningen, The Netherlands.
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MeSH Terms
Complement C3a / analogs & derivatives,  immunology
Infant, Newborn
Leukocyte Count
Leukocyte Elastase / immunology
Lymphocyte Activation / immunology*
Neutrophils / immunology*
Obstetric Labor, Premature
Platelet Activating Factor / immunology
Respiratory Distress Syndrome, Newborn / immunology*
Tumor Necrosis Factor-alpha / immunology
Ventilators, Mechanical
alpha 1-Antitrypsin / immunology
Reg. No./Substance:
0/Platelet Activating Factor; 0/Tumor Necrosis Factor-alpha; 0/alpha 1-Antitrypsin; 0/alpha 1-antitrypsin-leukocyte elastase complex; 0/complement C3a, des-Arg-(77)-; 80295-42-7/Complement C3a; EC Elastase

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