Document Detail

Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus.
MedLine Citation:
PMID:  18289512     Owner:  NLM     Status:  MEDLINE    
Status epilepticus (SE) can cause severe neuronal loss and oxidative damage. As peroxisome proliferator-activated receptor gamma (PPARgamma) agonists possess antioxidative activity, we hypothesize that rosiglitazone, a PPARgamma agonist, might protect the central nervous system (CNS) from oxidative damage in epileptic rats. Using a lithium-pilocarpine-induced SE model, we found that rosiglitazone significantly reduced hippocampal neuronal loss 1 week after SE, potently suppressed the production of reactive oxygen species (ROS) and lipid peroxidation. We also found that treatment with rosiglitazone enhanced antioxidative activity of superoxide dismutase (SOD) and glutathione hormone (GSH), together with decreased expression of heme oxygenase-1 (HO-1) in the hippocampus. The above effects of rosiglitazone can be blocked by co-treatment with PPARgamma antagonist T0070907. The current data suggest that rosiglitazone exerts a neuroprotective effect on oxidative stress-mediated neuronal damage followed by SE. Our data also support the idea that PPARgamma agonist might be a potential neuroprotective agent for epilepsy.
Xin Yu; Xiao-Guang Shao; Hong Sun; Yong-Nan Li; Jun Yang; Yan-Chun Deng; Yuan-Gui Huang
Publication Detail:
Type:  Journal Article     Date:  2008-01-26
Journal Detail:
Title:  Brain research     Volume:  1200     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  146-58     Citation Subset:  IM    
Research Center of Epilepsy, Department of Neurology, Xijing Hospital Fourth Military Medical University, 17 Changle West Road, Xi'an, Shaanxi 710032, China.
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MeSH Terms
Benzamides / pharmacology
Cell Death / drug effects,  physiology
Disease Models, Animal
Glutathione / metabolism
Heme Oxygenase (Decyclizing) / metabolism
Hippocampus / drug effects*,  metabolism,  physiopathology
Lipid Peroxidation / drug effects,  physiology
Muscarinic Agonists
Nerve Degeneration / drug therapy*,  etiology,  physiopathology
Neuroprotective Agents / pharmacology
Oxidative Stress / drug effects*,  physiology
PPAR gamma / agonists*,  antagonists & inhibitors,  metabolism
Pyridines / pharmacology
Rats, Sprague-Dawley
Reactive Oxygen Species / metabolism
Status Epilepticus / chemically induced,  drug therapy*,  physiopathology
Superoxide Dismutase / drug effects,  metabolism
Thiazolidinediones / pharmacology*
Reg. No./Substance:
0/Benzamides; 0/Convulsants; 0/Muscarinic Agonists; 0/Neuroprotective Agents; 0/PPAR gamma; 0/Pyridines; 0/Reactive Oxygen Species; 0/T 0070907; 0/Thiazolidinediones; 122320-73-4/rosiglitazone; 70-18-8/Glutathione; 7439-93-2/Lithium; 92-13-7/Pilocarpine; EC Oxygenase (Decyclizing); EC protein, rat; EC 1.15.1.-/superoxide dismutase 1; EC Dismutase

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