Document Detail

Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy.
MedLine Citation:
PMID:  20398658     Owner:  NLM     Status:  MEDLINE    
Adipose tissue secretes a variety of bioactive factors, which can regulate cardiomyocyte hypertrophy via reactive oxygen species (ROS). In the present study we investigated whether apelin affects ROS-dependent cardiac hypertrophy. In cardiomyocytes apelin inhibited the hypertrophic response to 5-HT and oxidative stress induced by 5-HT- or H(2)O(2) in a dose-dependent manner. These effects were concomitant to the increase in mRNA expression and activity of catalase. Chronic treatment of mice with apelin attenuated pressure-overload-induced left ventricular hypertrophy. The prevention of hypertrophy by apelin was associated with increased myocardial catalase activity and decreased plasma lipid hydroperoxide, as an index of oxidative stress. These results show that apelin behaves as a catalase activator and prevents cardiac ROS-dependent hypertrophy.
Camille Foussal; Olivier Lairez; Denis Calise; Atul Pathak; Celine Guilbeau-Frugier; Philippe Valet; Angelo Parini; Oksana Kunduzova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-14
Journal Detail:
Title:  FEBS letters     Volume:  584     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2363-70     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Institut National de la Sant? et de la Recherche M?dicale (INSERM), U858, Toulouse, France.
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MeSH Terms
Cardiomegaly / prevention & control*
Catalase / metabolism*
Hydrogen Peroxide / pharmacology*
Hypertrophy / metabolism
Hypertrophy, Left Ventricular / metabolism
Myocardium / metabolism
Myocytes, Cardiac / drug effects*
Oxidative Stress / drug effects*
Reactive Oxygen Species / metabolism
Serotonin / pharmacology
Reg. No./Substance:
0/Reactive Oxygen Species; 50-67-9/Serotonin; 7722-84-1/Hydrogen Peroxide; EC

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