| Activation of the carcinogen N-hydroxy-2-acetylaminofluorene by rat mammary peroxidase. | |
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MedLine Citation:
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PMID: 620717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A peroxidase preparation from rat mammary gland parenchymal cells, a target tissue of arylamine carcinogens, was shown to activate the carcinogen N-hydroxy-2-acetylaminofluorene via a nitroxyl free radical intermediate to the more active carcinogens nitrosofluorene and N-acetoxy-2-acetylaminofluorene. Hydrogen peroxide, cumene hydroperoxide, and linoleic acid hydroperoxide were effective as substrates. The antioxidants ascorbate, propyl gallate and reduced glutathione prevented the free radical activation route. |
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Authors:
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D L Reigh; M Stuart; R A Floyd |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experientia Volume: 34 ISSN: 0014-4754 ISO Abbreviation: Experientia Publication Date: 1978 Jan |
Date Detail:
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Created Date: 1978-03-10 Completed Date: 1978-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376547 Medline TA: Experientia Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 107-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology Carcinogens Cyclic N-Oxides Female Fluorenes* Free Radicals Hydroxyacetylaminofluorene* Mammary Glands, Animal / enzymology* Mice Peroxidases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Carcinogens; 0/Cyclic N-Oxides; 0/Fluorenes; 0/Free Radicals; 53-95-2/Hydroxyacetylaminofluorene; EC 1.11.1.-/Peroxidases |
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