Document Detail


Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants.
MedLine Citation:
PMID:  18536954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Gastric acid secretion is a complex process regulated by neuronal and hormonal pathways. Ex vivo studies in human gastric tissues indicate that the calcium sensing receptor (CaR), expressed on the surface of G and parietal cells, may be involved in this regulation. We sought to determine whether cinacalcet, a CaR allosteric agonist, increases serum gastrin and gastric acid secretion.
METHODS: Seventeen healthy adults with normal gastric acid output were placed on an 18-day metabolic diet. On day 8 (baseline), participants were given cinacalcet (15 then 30 mg/day) or placebo for 11 days. Changes in gastric acid output, serum gastrin, and other measures were compared in the two groups.
RESULTS: Changes in serum gastrin and basal acid output (adjusted for baseline body weight) were significantly more positive in the cinacalcet group compared with placebo (P = 0.004 and P = 0.039 respectively). Change in maximal acid output was similar in the two groups (P = 0.995). As expected, cinacalcet produced significant decreases in serum PTH (P < 0.001) and ionized calcium levels (P = 0.032), and increases in serum phosphorus levels (P = 0.001) and urinary calcium (P = 0.023).
CONCLUSIONS: This study provides in vivo evidence that activation of the CaR increases serum gastrin levels and basal gastric acid secretion in healthy adults.
Authors:
L Ceglia; S S Harris; H M Rasmussen; B Dawson-Hughes
Related Documents :
6307064 - Differentiation among inhibitory actions of omeprazole, cimetidine, and scn- on gastric...
17091214 - Mechanisms of acid and base secretion by the airway epithelium.
14992434 - Gastric electrical stimulation does not significantly affect canine gastric acid secret...
7137354 - Nutrient and bowel segment dependency of human intestinal control of gastric secretion.
18434144 - Identification of long chain alkylidenemalonates as novel small molecule modulators of ...
8007044 - Acetic acid intoxication by rectal administration.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-06-07
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  20     ISSN:  1433-2965     ISO Abbreviation:  Osteoporos Int     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-11-27     Completed Date:  2009-08-04     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-8     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00336739
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Calcium / blood,  metabolism,  urine
Creatinine / urine
Female
Gastric Acid / chemistry,  secretion*
Gastric Juice / chemistry
Gastric Mucosa / metabolism*,  secretion
Gastrins / analysis,  secretion*
Humans
Magnesium / urine
Male
Middle Aged
Naphthalenes / pharmacology*
Parathyroid Hormone / blood
Phosphorus / blood
Receptors, Calcium-Sensing / drug effects,  metabolism*
Stimulation, Chemical
Grant Support
ID/Acronym/Agency:
T32 DK007651/DK/NIDDK NIH HHS; T32 DK007651-16/DK/NIDDK NIH HHS; T32 DK007651-16/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Gastrins; 0/Naphthalenes; 0/Parathyroid Hormone; 0/Receptors, Calcium-Sensing; 27YLU75U4W/Phosphorus; AYI8EX34EU/Creatinine; I38ZP9992A/Magnesium; SY7Q814VUP/Calcium; UAZ6V7728S/cinacalcet
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Randomized, active-controlled study of once-weekly alendronate 280 mg high dose oral buffered soluti...
Next Document:  Hip fractures cluster in space: an epidemiological analysis in Portugal.