| Activation of c-Jun NH2-terminal kinase during islet isolation. | |
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MedLine Citation:
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PMID: 17124365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreatic islet transplantation has been remarkably improved by the Edmonton protocol; however, it is not easy to achieve insulin independence after islet transplantation from one donor pancreas. The islet isolation procedure itself destroys cellular and noncellular components of the pancreas that probably play a role in supporting islet survival. Further islet transplantation exposes cells to a variety of stressful stimuli such as proinflammatory cytokines. The reduction in islet mass immediately after isolation and transplantation implicates beta cell death by apoptosis and the prerecruitment of intracellular death signalling pathways. The c-Jun NH2-terminal kinases (JNKs) are classic stress-activated protein kinases and many cellular stresses have been shown to stimulate JNK activation. JNK in the pancreas is activated during brain death, pancreas procurement, and organ preservation, and its activity is progressively increased during the isolation procedure. Moreover, JNK activity in the transplanted liver after islet transplantation increases markedly within 24 hrs. Use of the JNK inhibitor in pancreas preservation, islet culture, and/or islet transplantation prevents islet apoptosis and improves islet graft function. These findings suggest that the control of JNK activation is important for pancreatic islet transplantation. |
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Authors:
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Hirofumi Noguchi |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-11-24 |
Journal Detail:
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Title: Endocrine journal Volume: 54 ISSN: 0918-8959 ISO Abbreviation: Endocr. J. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-05-18 Completed Date: 2007-10-02 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 169-76 Citation Subset: IM |
Affiliation:
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Diabetes Research Institute Japan, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Death Enzyme Activation Humans Islets of Langerhans / surgery* Islets of Langerhans Transplantation* JNK Mitogen-Activated Protein Kinases / metabolism* Organ Preservation Pancreas Tissue and Organ Harvesting / adverse effects* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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