| Activation of autophagy is required for muscle homeostasis during physical exercise. | |
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MedLine Citation:
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PMID: 22082869 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Skeletal muscle fibers of collagen VI null (Col6a1 (-/-) ) mice show signs of degeneration due to a block in autophagy, leading to the accumulation of damaged mitochondria and excessive apoptosis. Attempts to induce autophagic flux by subjecting these mutant mice to long-term or shorter bursts of physical activity are unsuccessful. In normal mice, the induction of autophagy in the skeletal muscles post-exercise is able to prevent the accumulation of damaged organelles and maintain cellular homeostasis. Thus, these studies provide an important connection between autophagy and exercise physiology. |
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Authors:
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Usha Nair; Daniel J Klionsky |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-01 |
Journal Detail:
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Title: Autophagy Volume: 7 ISSN: 1554-8635 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Life Sciences Institute; University of Michigan; Ann Arbor, MI USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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