| Activation of autophagy is required for muscle homeostasis during physical exercise. | |
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MedLine Citation:
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PMID: 22082869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skeletal muscle fibers of collagen VI null (Col6a12/2) mice show signs of degeneration due to a block in autophagy, leading to the accumulation of damaged mitochondria and excessive apoptosis. Attempts to induce autophagic flux by subjecting these mutant mice to long-term or shorter bursts of physical activity are unsuccessful (see Grumati, et al., pp. 1415–23). In normal mice, the induction of autophagy in the skeletal muscles post-exercise is able to prevent the accumulation of damaged organelles and maintain cellular homeostasis. Thus, these studies provide an important connection between autophagy and exercise physiology. |
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Authors:
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Usha Nair; Daniel J Klionsky |
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Publication Detail:
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Type: Comment; Editorial |
Journal Detail:
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Title: Autophagy Volume: 7 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-04-02 Completed Date: 2012-06-18 Revised Date: 2013-03-18 |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 1405-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autophagy* Collagen Type VI / deficiency* Muscle, Skeletal / metabolism*, pathology* Physical Conditioning, Animal* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM053396/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Col6a1 protein, mouse; 0/Collagen Type VI |
| Comments/Corrections | |
Comment On:
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Autophagy. 2011 Dec;7(12):1415-23
[PMID:
22024752
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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