Document Detail


Activation of autophagy in cells with abnormal karyotype.
MedLine Citation:
PMID:  23108329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of even one extra chromosome severely impairs cellular growth. This effect of aneuploidy (a term describing chromosome numbers deviating from multiples of haploid chromosome content) has been observed in many different organisms, from yeast to humans. Accordingly, abnormal karyotypes are detected in nearly 30% of spontaneously aborted embryos. The rarely surviving infants, such as with trisomy of chromosome 21, are severely handicapped. The causes remain enigmatic, although recent studies exploiting yeast and mouse models provided first glimpses of the imbalanced inner life of aneuploid cells. Using comparative genomics, transcriptomics and proteomics we have analyzed the fate of the transcripts and proteins coded on the extra chromosomes as well as the general response to aneuploidy in human cells.
Authors:
Silvia Stingele; Gabriele Stoehr; Zuzana Storchova
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Publication Detail:
Type:  Journal Article     Date:  2012-10-29
Journal Detail:
Title:  Autophagy     Volume:  9     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  2013-07-09     Revised Date:  2014-02-03    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormal Karyotype*
Aneuploidy
Animals
Autophagy*
Humans
Lysosomes / metabolism
Mice
Models, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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