| Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease. | |
| | |
MedLine Citation:
|
PMID: 20502937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the present study we demonstrated that neurotoxin MPP(+)-induced DNA damage is followed by ataxia telangiectasia muted (ATM) activation either in cerebellar granule cells (CGC) or in B65 cell line. In CGC, the selective ATM inhibitor KU-55933 showed neuroprotective effects against MPP(+)-induced neuronal cell loss and apoptosis, lending support to the key role of ATM in experimental models of Parkinson's disease. Likewise, we showed that knockdown of ATM levels in neuroblastoma B65 cells using an ATM-specific siRNA attenuates the phosphorylation of retinoblastoma protein without affecting other cell-cycle proteins involved in the G(0)/G(1) cell-cycle phase. Moreover, we demonstrated DNA damage, in human brain samples of PD patients. These findings support a model in which MPP(+) leads to ATM activation with a subsequent DNA damage response and activation of pRb. Therefore, this study demonstrates a new link between DNA damage by MPP(+) and cell-cycle re-entry through retinoblastoma protein phosphorylation. |
| | |
Authors:
|
Antoni Camins; Javier G Pizarro; Daniel Alvira; Javier Gutierrez-Cuesta; Aurelio Vazquez de la Torre; Jaume Folch; Francesc X Sureda; Ester Verdaguer; Felix Junyent; Joaquín Jordán; Isidre Ferrer; Mercè Pallàs |
Related Documents
:
|
20974137 - Csn5/jab1 controls multiple events in the mammalian cell cycle. 8321217 - Cell cycle regulation of the c-myc transcriptional activation domain. 3743667 - Autogamy in paramecium. cell cycle stage-specific commitment to meiosis. 9344627 - The duplication cycle in aspergillus nidulans. 1080957 - The fine structure of thymoma, with emphasis on its differential diagnosis. a study of ... 12365797 - Cyclosporine a-induced toxicity in two renal cell culture models (llc-pk1 and mdck). |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
|
Title: Cellular and molecular life sciences : CMLS Volume: 67 ISSN: 1420-9071 ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-18 Completed Date: 2010-11-16 Revised Date: 2011-11-02 |
Medline Journal Info:
|
Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 3865-82 Citation Subset: IM |
Affiliation:
|
Institut de Biomedicina, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Universitat de Barcelona, Spain. camins@ub.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
/
metabolism* Aged Aged, 80 and over Animals Apoptosis / drug effects Brain / pathology Cell Cycle Cell Cycle Proteins / metabolism* Cell Line Cells, Cultured Cerebellum / cytology* DNA Damage / drug effects* DNA-Binding Proteins / metabolism* Female Humans Male Middle Aged Morpholines / pharmacology Neurotoxins / pharmacology* Parkinson Disease / metabolism* Protein-Serine-Threonine Kinases / metabolism* Pyrones / pharmacology Rats Rats, Sprague-Dawley Tumor Suppressor Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; 0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/Morpholines; 0/Neurotoxins; 0/Pyrones; 0/Tumor Suppressor Proteins; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/ataxia telangiectasia mutated protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Health care utilisation and problems in accessing health care of female undocumented immigrants in t...
Next Document: Alkyltransferase-like proteins: molecular switches between DNA repair pathways.