| Activation of the alternative pathway of complement is an important component of hyperacute rejection of rabbit hearts by human blood. | |
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MedLine Citation:
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PMID: 14621809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperacute discordant xenograft rejection can be simulated by blood perfused working isolated heart. The survival of the heart is dependent on its functional integrity, and the preparation is thus sensitive to early myocardial damage. Perfusion of rabbit hearts with human blood results in immediate graft destruction by a thrombotic process. Prevention of this process results in rapid rejection at about 20 min by the alternative pathway of complement. |
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Authors:
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J Forty; R Hasan; N Cary; D J White; J Wallwork |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: 5 Suppl 1 ISSN: 0934-0874 ISO Abbreviation: Transpl. Int. Publication Date: 1992 |
Date Detail:
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Created Date: 2003-11-18 Completed Date: 2003-12-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: Germany |
Other Details:
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Languages: eng Pagination: S311-2 Citation Subset: IM |
Affiliation:
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Papworth Hospital, Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ABO Blood-Group System
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immunology Animals Complement Pathway, Alternative / immunology* Graft Rejection / diagnosis, pathology* Graft Survival / immunology* Heart / physiology* Humans Models, Biological Perfusion Rabbits Transplantation, Heterologous / immunology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/ABO Blood-Group System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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