Document Detail


Activation of TRPV1 Attenuates High Salt Induced Cardiac Hypertrophy through Improvement of Mitochondrial Function.
MedLine Citation:
PMID:  25339153     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: High salt diet induces cardiac remodelling and leads to heart failure, which is closely related to cardiac mitochondrial dysfunction. Transient receptor potential channels are implicated in the pathogenesis of cardiac dysfunction. We investigated whether activation of transient receptor potential vanilloid (subtype 1) (TRPV1) by dietary capsaicin can prevent high salt diet-induced cardiac hypertrophy through the improvement of cardiac mitochondrial dysfunction.
EXPERIMENTAL APPROACH: Male WT and TRPV1(-/-) mice on a high salt or normal diet were administrated with or without capsaicin for 6 months. Their cardiac parameters and endurance capacity were assessed. Mitochondrial respiration and oxygen consumption were measured using high-resolution respirometry. The expression levels of TRPV1, Sirt3, and NDUFA9 were detected in cardiac cells and tissues.
KEY RESULTS: Chronic high salt diet caused cardiac hypertrophy and physical performance reduction, which were improved by capsaicin intake in WT but not in TRPV1(-/-) mice. TRPV1 knockout or high salt diet significantly jeopardised mitochondrial Complex I OXPHOS capacity and reduced Complex I enzyme activity. Chronic dietary capsaicin increased cardiac mitochondrial Sirt3 expression, Complex I OXPHOS capacity, ATP production and Complex I enzyme activity in a TRPV1-dependent manner.
CONCLUSIONS AND IMPLICATIONS: TRPV1 activation by dietary capsaicin can antagonize high salt diet-mediated cardiac lesions by ameliorating Complex I OXPHOS capacity. TRPV1-mediated improvement in mitochondrial dysfunction may represent a novel target for management of early cardiac dysfunction.
Authors:
Hongmei Lang; Qiang Li; Hao Yu; Peng Li; Zongshi Lu; Shiqiang Xiong; Tao Yang; Yu Zhao; Xiaohu Huang; Peng Gao; Hexuan Zhang; Qianhui Shang; Daoyan Liu; Zhiming Zhu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-23
Journal Detail:
Title:  British journal of pharmacology     Volume:  -     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-23     Completed Date:  -     Revised Date:  2014-10-24    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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