Document Detail


Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies.
MedLine Citation:
PMID:  23150676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Babies of obese women are often large at birth, which is associated with perinatal complications and metabolic syndrome later in life. The mechanisms linking maternal obesity to fetal overgrowth are largely unknown.
OBJECTIVE: We tested the hypothesis that placental insulin/IGF-I and mammalian target of rapamycin (mTOR) signaling is activated and amino acid transporter activity is increased in large babies of obese women.
DESIGN AND SETTING: Pregnant women were recruited prospectively for collection of placental tissue at a university hospital and academic biomedical center.
PATIENTS OR OTHER PARTICIPANTS: Twenty-three Swedish pregnant women with first trimester body mass index ranging from 18.5 to 44.9 kg/m(2) and with uncomplicated pregnancies participated in the study.
INTERVENTIONS: There were no interventions.
MAIN OUTCOME MEASURES: We determined the phosphorylation of key signaling molecules (including Akt, IRS-1, S6K1, 4EBP-1, RPS6, and AMPK) in the placental insulin/IGF-I, AMPK, and mTOR signaling pathways. The activity and protein expression of the amino acid transporter systems A and L were measured in syncytiotrophoblast microvillous plasma membranes.
RESULTS: Birth weights (range, 3025-4235 g) were positively correlated to maternal body mass index (P < 0.05). The activity of placental insulin/IGF-I and mTOR signaling was positively correlated (P < 0.001), whereas AMPK phosphorylation was inversely (P < 0.05) correlated to birth weight. Microvillous plasma membrane system A, but not system L, activity and protein expression of the system A isoform SNAT2 were positively correlated to birth weight (P < 0.001).
CONCLUSIONS: Up-regulation of specific placental amino acid transporter isoforms may contribute to fetal overgrowth in maternal obesity. This effect may be mediated by activation of insulin/IGF-I and mTOR signaling pathways, which are positive regulators of placental amino acid transporters.
Authors:
Nina Jansson; Fredrick J Rosario; Francesca Gaccioli; Susanne Lager; Helen N Jones; Sara Roos; Thomas Jansson; Theresa L Powell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-12
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  98     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-03-07     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-13     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Transport Systems / agonists,  metabolism*
Birth Weight / physiology
Body Mass Index
Cohort Studies
Female
Fetal Macrosomia / etiology,  metabolism*
Humans
Infant, Newborn
Insulin-Like Growth Factor I / metabolism
Obesity / complications,  metabolism*,  pathology
Placenta / metabolism*,  pathology
Pregnancy
Pregnancy Complications / metabolism*,  pathology
Signal Transduction / physiology
TOR Serine-Threonine Kinases / metabolism*
Young Adult
Grant Support
ID/Acronym/Agency:
DK89989/DK/NIDDK NIH HHS; HD68370/HD/NICHD NIH HHS; R01 DK089989/DK/NIDDK NIH HHS; R01 HD068370/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acid Transport Systems; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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