Document Detail

Activation of PAR1 in the lateral hypothalamus of rats enhances food intake and REMS through CB1R.
MedLine Citation:
PMID:  22889888     Owner:  NLM     Status:  Publisher    
The activation of protease-activated receptor 1 (PAR1) in cultured rat hippocampal neurons triggers synaptic retrograde signaling through the endocannabinoid 2-arachidonoylglycerol, thereby activating the cannabinoid receptor 1 (CB1R). CB1R is a metabotropic receptor activated by marihuana and endocannabinoids that suppresses neurotransmitter release. Also, activation of the CB1R increases rapid eye movement sleep (REMS) and food intake. The lateral hypothalamus is a crucial structure to modulate both feeding and waking. To evaluate the effect of PAR1 stimulation in the lateral hypothalamus on food intake and on the sleep-waking cycle, we implanted rats with electrodes, for recording sleep, and cannulae, to administer S1820, a selective PAR1 agonist peptide, bilaterally into the lateral hypothalamus. To determine whether the effects induced by PAR1 stimulation were mediated by CB1R activation, we administered AM251, a CB1R inverse agonist, to block S1820 effects. Our results show that the stimulation of PAR1 into the lateral hypothalamus increases both food intake and REMS and such effects were prevented by AM251, indicating that PAR1 modulates both food intake and the sleep-waking cycle, in the lateral hypothalamus, through CB1R activation. This study shows novel behavioral changes induced by PAR1 activation and further supports the notion that endocannabinoids are food intake and REMS promoters.
Marcel Pérez-Morales; Ilia Alvarado-Capuleño; Ana M López-Colomé; Mónica Méndez-Díaz; Alejandra E Ruiz-Contreras; Oscar Prospéro-García
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  Neuroreport     Volume:  -     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aLaboratory of Cannabinoids, Department of Physiology, School of Medicine bNeuroscience Division, Institute of Cellular Physiology cLaboratory of Cognitive Neurogenomics, National Autonomus University of México (UNAM), DF, México.
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