Document Detail


Activation of Notch signaling in human tongue carcinoma.
MedLine Citation:
PMID:  20819128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Involvement of Notch signaling in several tumors is well known, but its role in tongue squamous cell carcinoma remains poorly characterized. The purpose of this study was to evaluate the roles of Notch signaling in the oncogenesis of tongue carcinoma.
MATERIALS AND METHODS: Tumor specimens and adjacent non-neoplastic tongue tissues from 74 patients with tongue carcinoma and human tongue carcinoma cell line Tca8113 were examined using immunohistochemistry and RT-PCR to determine the expressions of Notch1, Notch3, Jagged1, and Jagged2.
RESULTS: The mRNA expressions of Notch1, Notch3, Jagged1, and Jagged2 were detected in Tca8113, tongue carcinoma, and adjacent non-neoplastic tongue tissues. The expression levels of mRNAs in tongue carcinoma were higher than those in adjacent non-neoplastic tongue tissues (P < 0.05). Immunohistochemical examination showed that the Notch signal molecules were expressed in Tca8113, tongue carcinoma, and adjacent non-neoplastic tongue tissues. The expression rates of Notch1 and Notch3 protein in tongue carcinoma were higher than those in adjacent non-neoplastic tongue tissues (χ² = 6.10, P = 0.013; χ² = 3.94, P = 0.047). Notch1 and jagged1 were significantly more highly expressed in lymph node metastasis-positive tongue carcinoma (χ² = 6.108, P = 0.013; χ² = 7.354, P = 0.025). In addition, expressions of Notch3 and Jagged2 were highly correlated in tongue carcinoma tissues (χ² = 42.130, P < 0.001).
CONCLUSIONS: Expressions of Notch receptors and ligands in tongue carcinoma and adjacent non-neoplastic tongue tissues suggest that Notch signaling may control cell differentiation and proliferation of carcinoma cells. The disorder of Notch signaling may be a mechanism of the tongue carcinoma development.
Authors:
Tong-Han Zhang; Hai-Chao Liu; Li-Jun Zhu; Mei Chu; Yu-Jie Liang; Li-Zhong Liang; Gui-Qing Liao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-31
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  40     ISSN:  1600-0714     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-06-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  37-45     Citation Subset:  D; IM    
Copyright Information:
© 2010 The Authors. Journal of Oral Pathology & Medicine © 2010 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Calcium-Binding Proteins / genetics,  metabolism
Carcinoma, Squamous Cell / genetics,  metabolism*,  pathology
Case-Control Studies
Cell Line, Tumor
Female
Humans
Immunohistochemistry
Intercellular Signaling Peptides and Proteins / genetics,  metabolism
Lymphatic Metastasis
Male
Membrane Proteins / genetics,  metabolism
Middle Aged
RNA, Messenger / analysis
Receptor, Notch1 / genetics,  metabolism
Receptors, Notch / genetics,  metabolism*
Reference Values
Second Messenger Systems / genetics,  physiology
Signal Transduction / genetics,  physiology*
Tongue / metabolism*
Tongue Neoplasms / genetics,  metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/JAG2 protein, human; 0/Membrane Proteins; 0/NOTCH1 protein, human; 0/NOTCH3 protein, human; 0/RNA, Messenger; 0/Receptor, Notch1; 0/Receptors, Notch; 134324-36-0/Serrate proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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