Document Detail


Activation of NMDA and non-NMDA receptors in the caudal ventrolateral medulla dilates the airways.
MedLine Citation:
PMID:  9915633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The caudal ventrolateral medulla (CVLM) participates in the central control of airway caliber. For example, both electrical and chemical stimulation of the CVLM decrease total lung resistance by withdrawing cholinergic input to airway smooth muscle. Although cell bodies in the CVLM have been shown to play an important role in mediating the central control of airway caliber, the pharmacological mechanism in this brainstem region responsible for causing this airway dilation is unknown. We, therefore, examined the role played by ionotropic excitatory amino acid receptors in the CVLM in the control of airway caliber in chloralose-anesthetized dogs. We found that microinjection of 3.9 pmol of NMDA or AMPA or quisqualate into 12 sites in the CVLM decreased total lung resistance by 1.5 +/- 0.2 cm H2O l(-1) s(-1) (p < 0.05), and that microinjection of 3.9 pmol of kainic acid into 9 in the CVLM decreased total lung resistance by 0.5 +/- 0.1 cm H2O l(-1) s(-1) (p < 0.05). The decrease in total lung resistance evoked by either NMDA or AMPA or quisqualate was not different (p > 0.05) while that evoked by kainic acid was significantly smaller. Additionally, microinjection of NMDA or AMPA or quisqualate caused a small but significant decrease in mean arterial pressure and heart rate (p < 0.05). These experiments demonstrate that the airway dilation evoked by stimulation of excitatory amino acid receptors in the CVLM is mediated by both NMDA and non-NMDA receptors.
Authors:
I C Solomon
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  74     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-07     Completed Date:  1999-04-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of California-Davis, 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine Derivatives / pharmacology
Autonomic Nervous System / chemistry,  drug effects,  physiology
Bronchoconstriction / drug effects,  physiology*
Cholinergic Fibers / drug effects,  physiology*
Dogs
Electric Stimulation
Excitatory Amino Acid Agonists / pharmacology
Female
Kainic Acid / pharmacology
Lung / innervation*,  physiology
Male
Medulla Oblongata / chemistry*,  drug effects,  physiology
Muscle, Smooth / innervation,  physiology
N-Methylaspartate / pharmacology
Parasympatholytics / pharmacology
Quisqualic Acid / pharmacology
Receptors, N-Methyl-D-Aspartate / physiology*
Stimulation, Chemical
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / pharmacology
Grant Support
ID/Acronym/Agency:
HL 40910/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Atropine Derivatives; 0/Excitatory Amino Acid Agonists; 0/Parasympatholytics; 0/Receptors, N-Methyl-D-Aspartate; 31610-87-4/methylatropine; 487-79-6/Kainic Acid; 52809-07-1/Quisqualic Acid; 6384-92-5/N-Methylaspartate; 77521-29-0/alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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