Document Detail


Activation and inhibition of neurons in the hippocampal ventral subiculum by norepinephrine and locus coeruleus stimulation.
MedLine Citation:
PMID:  23032074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ventral subiculum (vSub) has been implicated in a wide range of neurocognitive functions, including responses to fear, stress, and anxiety. The vSub receives dense noradrenergic (NE) inputs from the locus coeruleus (LC), and the LC-NE system is heavily implicated in attention and is known to be activated by stressors. However, the way in which the neurons in the vSub respond to activation of the LC-NE is not well understood. In this study, the direct LC innervation of the vSub was investigated. The effect of norepinephrine (NE) on single vSub neurons was examined using microiontophoresis combined with electrophysiological recordings in anesthetized rats, and this response compared with the effect of electrical stimulation of the LC. Iontophoretic NE inhibited all vSub neurons tested, whereas LC stimulation inhibited 16% and activated 38% of neurons. Inhibition was mediated primarily by alpha-2 receptors, whereas activation was mediated by beta-adrenergic receptors. Furthermore, this effect was not mediated via the LC-basolateral amygdala (BLA) pathway, because BLA inactivation did not block LC stimulation-evoked activation of the vSub. These results indicate that the LC-NE system is a potent modulator of vSub activity. Based on these findings, stress-induced activation of the LC-NE system is expected to evoke inhibition and activation in the vSub, both of which may contribute to stress adaptation, whereas an imbalance of this system may lead to pathological stress responses in mental disorders.
Authors:
Witold J Lipski; Anthony A Grace
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-03
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  38     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-10-17     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  285-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Electric Stimulation / methods
Hippocampus / drug effects,  physiology*
Iontophoresis / methods
Locus Coeruleus / drug effects,  physiology*
Male
Neural Inhibition / drug effects,  physiology*
Neurons / drug effects,  physiology*
Norepinephrine / administration & dosage*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DA15408/DA/NIDA NIH HHS; MH086400/MH/NIMH NIH HHS; MH57440/MH/NIMH NIH HHS; R01 DA015408/DA/NIDA NIH HHS; R01 MH057440/MH/NIMH NIH HHS; R37 MH057440/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
X4W3ENH1CV/Norepinephrine
Comments/Corrections

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