| Activation of GABAA and opioid receptors reduce penile erection induced by hexarelin peptides. | |
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MedLine Citation:
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PMID: 14643856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of muscimol, a GABA(A) receptor agonist, and of morphine, an opioid receptor agonist, on penile erection induced by the hexarelin analogue peptide EP 80661 (GAB-D-Trp(2-Me)-D-Trp(2-Me)-LysNH(2)) and on the increase in the concentration of NO(2)(-) and NO(3)(-) that occurs concomitantly in the dialysate obtained from the paraventricular nucleus (PVN) of the hypothalamus by intracerebral microdialysis, was studied in male rats. Muscimol (50, 100 and 200 ng) and morphine (0.1, 0.5, 1 and 5 microg) given into the PVN dose-dependently reduced penile erection induced by EP 80661 (1 microg) injected into the PVN. The reduction of penile erection was parallel to a decrease of the concomitant NO(2)(-) and NO(3)(-) increase that occurs in the paraventricular dialysate in these experimental conditions. Muscimol and morphine effects on EP 80661-induced penile erection and NO(2)(-) increase were prevented by the prior administration into the PVN of bicuculline (250 ng) and naloxone (5 microg), respectively. The present results show that the activation of GABA(A) receptors and of opioid receptors in the PVN reduces penile erection induced by hexarelin analogue peptides by reducing the increase in NO activity that occurs in this hypothalamic nucleus in these experimental conditions. |
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Authors:
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Salvatora Succu; Maria Stefania Mascia; Tiziana Melis; Maria Rosaria Melis; Romano Deghenghi; Antonio Argiolas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 76 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-08-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 563-70 Citation Subset: IM |
Affiliation:
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Bernard B. Brodie Department of Neuroscience and Center of Excellence for the Neurobiology of Addictions, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, Km 0.700, 09042 Monserrato (CA), Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Drug GABA Agonists / pharmacology* Male Microdialysis Microinjections Morphine / pharmacology Muscimol / pharmacology Narcotics / pharmacology Nitrates / metabolism Nitric Oxide / biosynthesis Oligopeptides / antagonists & inhibitors*, pharmacology* Paraventricular Hypothalamic Nucleus / drug effects, metabolism, physiology Penile Erection / drug effects* Peptides / pharmacology Rats Rats, Sprague-Dawley Receptors, GABA-A / drug effects* Receptors, Opioid / agonists* |
| Chemical | |
Reg. No./Substance:
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0/EP 80661; 0/GABA Agonists; 0/Narcotics; 0/Nitrates; 0/Oligopeptides; 0/Peptides; 0/Receptors, GABA-A; 0/Receptors, Opioid; 10102-43-9/Nitric Oxide; 140703-51-1/hexarelin; 2763-96-4/Muscimol; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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