Document Detail


Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids.
MedLine Citation:
PMID:  18499755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
G protein-coupled receptor 43 (GPR43) has been identified as a receptor for short-chain fatty acids that include acetate and propionate. A potential involvement of GPR43 in immune and inflammatory response has been previously suggested because its expression is highly enriched in immune cells. GPR43 is also expressed in a number of other tissues including adipocytes; however, the functional consequences of GPR43 activation in these other tissues are not clear. In this report, we focus on the potential functions of GPR43 in adipocytes. We show that adipocytes treated with GPR43 natural ligands, acetate and propionate, exhibit a reduction in lipolytic activity. This inhibition of lipolysis is the result of GPR43 activation, because this effect is abolished in adipocytes isolated from GPR43 knockout animals. In a mouse in vivo model, we show that the activation of GPR43 by acetate results in the reduction in plasma free fatty acid levels without inducing the flushing side effect that has been observed by the activation of nicotinic acid receptor, GPR109A. These results suggest a potential role for GPR43 in regulating plasma lipid profiles and perhaps aspects of metabolic syndrome.
Authors:
Hongfei Ge; Xiaofan Li; Jennifer Weiszmann; Ping Wang; Helene Baribault; Jin-Long Chen; Hui Tian; Yang Li
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Publication Detail:
Type:  Journal Article     Date:  2008-05-22
Journal Detail:
Title:  Endocrinology     Volume:  149     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4519-26     Citation Subset:  AIM; IM    
Affiliation:
Amgen Inc., 1120 Veterans Boulevard, South San Francisco, California 94080, USA.
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MeSH Terms
Descriptor/Qualifier:
3T3-L1 Cells
Acetic Acid / pharmacology
Adipocytes / drug effects,  metabolism*
Animals
Down-Regulation
Fatty Acids, Nonesterified / blood*
Flushing / chemically induced
Lipolysis / drug effects,  genetics*
Male
Metabolic Syndrome X / genetics
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Obese
Niacin / pharmacology
Propionic Acids / pharmacology
Receptors, G-Protein-Coupled / genetics,  metabolism,  physiology*
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Ffar2 protein, mouse; 0/Propionic Acids; 0/Receptors, G-Protein-Coupled; 59-67-6/Niacin; 64-19-7/Acetic Acid; 79-09-4/propionic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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