Document Detail


Activation of ERα is necessary for estradiol's anorexigenic effect in female rats.
MedLine Citation:
PMID:  20807534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While there is considerable evidence that the ovarian hormone estradiol reduces food intake in female rats, it is unclear which estrogen receptor (ER) subtype, ERα or ERβ, mediates this effect. While several studies have demonstrated that activation of ERα, but not ERβ, is sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding which receptor subtype is necessary. Here we used the selective ERα and ERß antagonists, MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of ERα, but not ERβ, prevented the decrease in food intake following acute administration of estradiol in OVX rats. In addition, antagonism of ERα prevented the estrous-related, phasic reduction in food intake that occurs in response to the rise in circulating levels of estradiol in cycling rats. We conclude that activation of ERα is necessary for the anorexigenic effects of exogenous and endogenous estradiol in female rats.
Authors:
Jessica Santollo; Benita S Katzenellenbogen; John A Katzenellenbogen; Lisa A Eckel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-08-31
Journal Detail:
Title:  Hormones and behavior     Volume:  58     ISSN:  1095-6867     ISO Abbreviation:  Horm Behav     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2011-03-08     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  872-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Program in Neuroscience, Florida State University, Tallahassee, FL 32306-4301, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anorexia / chemically induced*,  metabolism
Appetite Depressants / pharmacology
Drug Evaluation, Preclinical
Eating / drug effects,  physiology
Estradiol / pharmacology*,  physiology
Estrogen Receptor alpha / agonists*,  metabolism,  physiology
Female
Ovariectomy
Piperidines / pharmacology
Pyrazoles / pharmacology
Pyrimidines / pharmacology
Rats
Rats, Long-Evans
Selective Estrogen Receptor Modulators / pharmacology
Grant Support
ID/Acronym/Agency:
CA-018119/CA/NCI NIH HHS; DK-015556/DK/NIDDK NIH HHS; DK-073936/DK/NIDDK NIH HHS; NS-062667/NS/NINDS NIH HHS; R01 DK073936-04/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole; 0/4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol; 0/Appetite Depressants; 0/Estrogen Receptor alpha; 0/Piperidines; 0/Pyrazoles; 0/Pyrimidines; 0/Selective Estrogen Receptor Modulators; 50-28-2/Estradiol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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