| Activation of AMP-activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis. | |
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MedLine Citation:
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PMID: 20564492 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Corosolic acid is one of the triterpenoids present in the leaves of Weigela subsessilis. The antidiabetic activity of corosolic acid has been reported previously, but to date, the anticancer effects on gastric cancer have been poorly studied. In this study, corosolic acid showed growth inhibition on SNU-601 human gastric cancer cells, with an IC₅₀ value of 16.9 ± 2.9 μM. Corosolic acid also triggered the activation of caspase-3 and poly (ADP-ribose) polymerase, while it was recovered by Z-VAD-FMK. Moreover, the cell growth/apoptosis activities of corosolic acid were regulated by the AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) signals. These results showed that corosolic acid-mediated AMPK activation leads to inhibition of mTOR, thus providing a possible mechanism of action of corosolic acid in the inhibition of cancer cell growth and the induction of apoptosis. |
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Authors:
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Myung Sun Lee; Chang Min Lee; Eun Young Cha; Phuong Thien Thuong; KiHwan Bae; In Sang Song; Seung Moo Noh; Ji Young Sul |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 24 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 1857-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Regional Cancer Institute, Chungnam National University Hospital, Daejeon, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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