Document Detail

Activating transcription factor 3 interferes with p21 activation in histone deacetylase inhibitor-induced growth inhibition of epidermoid carcinoma cells.
MedLine Citation:
PMID:  25371069     Owner:  NLM     Status:  Publisher    
Inhibition of histone deacetylase (HDAC) activity by HDAC inhibitors (HDACis) results in cancer cell growth inhibition, and HDACis have been revealed as potential anti-skin cancer agents. p21 is a cyclin-dependent kinase inhibitor and an essential regulator of growth inhibition. Recently, we reported that activating transcription factor 3 (ATF3) could significantly promote skin cancer cell growth. This study explored the relationship between ATF3 and HDACi-induced growth inhibition of epidermoid carcinoma cells. We found that trichostatin A (TSA) treatment inhibited cell growth in A431 epidermoid carcinoma cells in a dose-dependent manner. Simultaneously, p21 and ATF3 expression levels were upregulated and downregulated upon TSA stimulation, respectively. ATF3 overexpression promoted cell growth and downregulated p21 expression. In contrast, ATF3 depletion resulted in cell growth reduction and p21 transcriptional upregulation. More importantly, ATF3 overexpression partially antagonized TSA-induced growth inhibition and p21 activation. Collectively, these data demonstrate that ATF3 acts as an essential negative regulator of TSA-induced cell growth inhibition through interfering with TSA-induced p21 activation.
Zhen-Feng Hao; You-Ming Su; Cong-Min Wang; Rong-Ya Yang
Related Documents :
25328549 - Cell localisation of gadolinium-based nanoparticles and related radiosensitising effica...
25228759 - B-1a transitional cells are phenotypically distinct and are lacking in mice deficient i...
21427239 - Contact by melanoma cells causes malignant transformation of human epithelial-like stem...
21508359 - The effect of pten on serotonin synthesis and secretion from the carcinoid cell line bon.
25364659 - Glycyrrhetinic acid inhibits cell growth and induces apoptosis in ovarian cancer a2780 ...
25307309 - Role of chk2 inhibitors in the cellular responses to ionizing radiation.
11287479 - Mouse taste cells with glialike membrane properties.
8262359 - Morphological changes in the thecal layer during the maturation of the preovulatory ova...
5273899 - Viruslike particles in nuclei of cultured plant cells which have lost the ability to di...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-5
Journal Detail:
Title:  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine     Volume:  -     ISSN:  1423-0380     ISO Abbreviation:  Tumour Biol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-5     Completed Date:  -     Revised Date:  2014-11-6    
Medline Journal Info:
Nlm Unique ID:  8409922     Medline TA:  Tumour Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cardiomyopathy in murine models of systemic sclerosis.
Next Document:  Combinatorial immunotherapy of sorafenib and blockade of programmed death-ligand 1 induces effective...