Document Detail

Activated tissue renin-angiotensin systems add to the progression of heart failure.
MedLine Citation:
PMID:  8957550     Owner:  NLM     Status:  MEDLINE    
In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin systems are activated in heart failure; c) activated tissue renin-angiotensin systems induce cardiovascular dysfunction. Finally, this hypothesis predicts that optimal treatment in heart failure requires the inhibition of tissue renin-angiotensin systems. However, studies pertaining to this prediction are still lacking, particularly in human subjects.
Y M Pinto; H Buikema; W H van Gilst; K I Lie
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Basic research in cardiology     Volume:  91 Suppl 2     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  1996  
Date Detail:
Created Date:  1997-03-12     Completed Date:  1997-03-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  IM    
Dept. of Cardiology, University of Groningen, The Netherlands.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Disease Progression
Heart Failure / drug therapy,  etiology*,  pathology
Renin-Angiotensin System / drug effects,  physiology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors

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