| Activated protein C resistance in cord blood from healthy and complicated newborns. | |
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MedLine Citation:
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PMID: 17853185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Newborns are susceptible to thrombosis secondary to the immature hemostatic system and maternal and fetal complications. The contribution of activated protein C resistance (APCR) to thrombosis tendency has not yet been established. This study was conducted to investigate the effects of maternal and fetal complications on APCR levels. METHODS: APCR levels were determined in cord blood from healthy term infants and compared with those in healthy preterm and complicated neonates as well as that in adult venous blood. RESULTS: The mean value of APCR in cord blood from healthy term infants (166 +/- 40 s) was not significantly different from that in adult venous blood (173 +/- 40 s). No significant differences in the mean cord blood APCR values were observed between healthy term and preterm infants, infants with vaginal and cesarean delivery, infants from preeclamptic and non-eclamptic mothers, and infants with or without perinatal asphyxia. The activity levels of protein C, protein S, and antithrombin III were not significantly different between these groups except for lower levels in preterm babies. CONCLUSIONS: The level of APCR in cord blood is comparable to that in adults and not influenced by maternal and fetal complications. It appears that APCR does not contribute to the thrombotic tendency in newborns. |
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Authors:
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Turkiz Gursel; Ulker Kocak; Zuhre Kaya; Aysegul Bukulmez; Yildiz Atalay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 20 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-12-07 Completed Date: 2008-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
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Languages: eng Pagination: 797-801 Citation Subset: IM |
Affiliation:
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Pediatric Hematology Unit, Department of Pediatrics, Gazi University School of Medicine, Ankara, Turkey. turkiz@gazi.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activated Protein C Resistance
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complications* Adolescent Adult Antithrombin III / metabolism Asphyxia Neonatorum / blood* Case-Control Studies Female Fetal Blood / chemistry* Humans Infant, Newborn Infant, Premature / blood* Pre-Eclampsia / blood* Pregnancy Protein C / metabolism Protein S / metabolism Thrombosis / etiology* |
| Chemical | |
Reg. No./Substance:
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0/Protein C; 0/Protein S; 9000-94-6/Antithrombin III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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