Document Detail


Activated protein C resistance in cord blood from healthy and complicated newborns.
MedLine Citation:
PMID:  17853185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Newborns are susceptible to thrombosis secondary to the immature hemostatic system and maternal and fetal complications. The contribution of activated protein C resistance (APCR) to thrombosis tendency has not yet been established. This study was conducted to investigate the effects of maternal and fetal complications on APCR levels. METHODS: APCR levels were determined in cord blood from healthy term infants and compared with those in healthy preterm and complicated neonates as well as that in adult venous blood. RESULTS: The mean value of APCR in cord blood from healthy term infants (166 +/- 40 s) was not significantly different from that in adult venous blood (173 +/- 40 s). No significant differences in the mean cord blood APCR values were observed between healthy term and preterm infants, infants with vaginal and cesarean delivery, infants from preeclamptic and non-eclamptic mothers, and infants with or without perinatal asphyxia. The activity levels of protein C, protein S, and antithrombin III were not significantly different between these groups except for lower levels in preterm babies. CONCLUSIONS: The level of APCR in cord blood is comparable to that in adults and not influenced by maternal and fetal complications. It appears that APCR does not contribute to the thrombotic tendency in newborns.
Authors:
Turkiz Gursel; Ulker Kocak; Zuhre Kaya; Aysegul Bukulmez; Yildiz Atalay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  20     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-07     Completed Date:  2008-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  797-801     Citation Subset:  IM    
Affiliation:
Pediatric Hematology Unit, Department of Pediatrics, Gazi University School of Medicine, Ankara, Turkey. turkiz@gazi.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Activated Protein C Resistance / complications*
Adolescent
Adult
Antithrombin III / metabolism
Asphyxia Neonatorum / blood*
Case-Control Studies
Female
Fetal Blood / chemistry*
Humans
Infant, Newborn
Infant, Premature / blood*
Pre-Eclampsia / blood*
Pregnancy
Protein C / metabolism
Protein S / metabolism
Thrombosis / etiology*
Chemical
Reg. No./Substance:
0/Protein C; 0/Protein S; 9000-94-6/Antithrombin III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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