Document Detail

Activated protein C resistance in young African American patients with ischemic stroke.
MedLine Citation:
PMID:  10371074     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been proposed that activated protein C resistance (APCR) due to the factor V Leiden (FVL) mutation may be a risk factor for stroke in young adults. However, this may not be the case for all ethnic groups due to variability in the prevalence of the FVL mutation. METHODS: Case series from a university neurology clinic. Patients with an APCR ratio of 2.2 or below were tested for the FVL mutation (nine patients). Patients on warfarin were also tested for the FVL mutation (14 patients). RESULTS: 38 African American patients under age 55 with an arterial stroke were identified. The mean age of the patients is 43.1 years. Five percent had an APCR ratio of 2.0 or below. None of the patients with an APCR ratio of 2.2 or below or the patients directly tested for the FVL mutation had the mutant allele. CONCLUSIONS: Activated protein C resistance due to the FVL mutation does not appear to be a major risk factor for stroke in young African Americans. Other, as yet unidentified, mechanisms leading to activated protein C resistance may be important in a small subset of young African American stroke patients.
S Chaturvedi; N Joshi; J Dzieczkowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  163     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-07-23     Completed Date:  1999-07-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  137-9     Citation Subset:  IM    
Department of Neurology, Wayne State University/Detroit Medical Center, MI 48201, USA.
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MeSH Terms
Activated Protein C Resistance / complications*,  genetics*
African Americans
African Continental Ancestry Group / genetics
Brain Ischemia / epidemiology,  genetics*
Cohort Studies
Factor V / genetics*
Hospitals, University
Medical Records
Middle Aged
Point Mutation
Risk Factors
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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