| Activated partial thromboplastin time and clinical outcome after thrombin inhibition in unstable coronary artery disease. | |
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MedLine Citation:
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PMID: 10543929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSIONS: Higher activated partial thromboplastin time levels during inogatran treatment are related to increased risk of death, myocardial infarction or refractory angina. This might, at least in part, be explained by differences in anticoagulant mechanisms between direct thrombin inhibitors and heparin, and further emphasizes the poorly defined optimal activated partial thromboplastin time range during treatment with direct thrombin inhibitors in unstable coronary artery disease. |
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Authors:
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J Oldgren; R Linder; L Grip; A Siegbahn; L Wallentin |
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Publication Detail:
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Type: Clinical Trial; Comment; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European heart journal Volume: 20 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-19 Completed Date: 2000-01-19 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1657-66 Citation Subset: IM |
Copyright Information:
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Copyright 1999 The European Society of Cardiology. |
Affiliation:
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Department of Cardiology, Uppsala University Hospital, Uppsala. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angina, Unstable / blood, drug therapy*, mortality Antithrombins / administration & dosage*, adverse effects Cause of Death Coronary Disease / blood, drug therapy*, mortality Dose-Response Relationship, Drug Female Glycine / administration & dosage, adverse effects, analogs & derivatives* Heparin / administration & dosage, adverse effects Humans Infusions, Intravenous Male Middle Aged Myocardial Infarction / blood, drug therapy*, mortality Partial Thromboplastin Time* Piperidines / administration & dosage*, adverse effects Survival Rate Thrombin / antagonists & inhibitors*, metabolism Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antithrombins; 0/Piperidines; 428409I84L/inogatran; 56-40-6/Glycine; 9005-49-6/Heparin; EC 3.4.21.5/Thrombin |
| Comments/Corrections | |
Comment On:
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Eur Heart J. 1997 Sep;18(9):1416-25
[PMID:
9458447
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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