Document Detail


Activated and inactivated renin-angiotensin system in transgenic animals: from genes to blood pressure.
MedLine Citation:
PMID:  9150489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Much of our knowledge about blood pressure regulation has come from a huge number of biochemical, endocrinologic, pharmacologic, clinical, and physiologic studies. The renin-angiotensin system, composed of enzymatic and signal-transduction cascades, has a key role in regulating arterial blood pressure and in developing certain forms of experimentally induced hypertension and hypertension in human beings. Angiotensin peptides, the products of this system, exert a wide range of physiologically important effects on many tissues, including those of the cardiovascular system, through their actions on angiotensin receptors. Recently, several groups have succeeded in generating animals transgenic for the renin or angiotensinogen genes, or with a targeted disruption of the component genes of the renin-angiotensin system. This brief review describes advances of the in vivo analysis of blood pressure regulation by focusing on the renin-angiotensin system.
Authors:
A Fukamizu; K Murakami
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Laboratory animal science     Volume:  47     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-10     Completed Date:  1997-07-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-31     Citation Subset:  IM    
Affiliation:
Institute of Applied Biochemistry, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Angiotensin II / chemistry,  genetics
Animals
Animals, Genetically Modified*
Blood Pressure*
Humans
Hypertension
Renin / genetics
Renin-Angiotensin System / genetics,  physiology*
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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