| Activated human CD4+ T cells express transporters for both cysteine and cystine. | |
MedLine Citation:
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PMID: 22355778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because naïve T cells are unable to import cystine due to the absence of cystine transporters, it has been suggested that T cell activation is dependent on cysteine generated by antigen presenting cells. The aim of this study was to determine at which phases during T cell activation exogenous cystine/cysteine is required and how T cells meet this requirement. We found that early activation of T cells is independent of exogenous cystine/cysteine, whereas T cell proliferation is strictly dependent of uptake of exogenous cystine/cysteine. Naïve T cells express no or very low levels of both cystine and cysteine transporters. However, we found that these transporters become strongly up-regulated during T cell activation and provide activated T cells with the required amount of cystine/cysteine needed for T cell proliferation. Thus, T cells are equipped with mechanisms that allow T cell activation and proliferation independently of cysteine generated by antigen presenting cells. |
Authors:
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Trine Bøegh Levring; Ann Kathrine Hansen; Bodil Lisbeth Nielsen; Martin Kongsbak; Marina Rode von Essen; Anders Woetmann; Niels Odum; Charlotte Menné Bonefeld; Carsten Geisler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-02-14 |
Journal Detail:
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Title: Scientific reports Volume: 2 ISSN: 2045-2322 ISO Abbreviation: Sci Rep Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-22 Completed Date: 2013-04-12 Revised Date: 2013-06-26 |
Medline Journal Info:
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Nlm Unique ID: 101563288 Medline TA: Sci Rep Country: England |
Other Details:
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Languages: eng Pagination: 266 Citation Subset: IM |
Affiliation:
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Department of International Health, Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3 , Copenhagen DK-2200, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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CD4-Positive T-Lymphocytes
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metabolism* Cells, Cultured Cysteine / metabolism* Cystine / metabolism* Humans Lymphocyte Activation* Membrane Transport Proteins / metabolism* Polymerase Chain Reaction Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Membrane Transport Proteins; 52-90-4/Cysteine; 56-89-3/Cystine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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