Document Detail

Activated human CD4+ T cells express transporters for both cysteine and cystine.
MedLine Citation:
PMID:  22355778     Owner:  NLM     Status:  MEDLINE    
Because naïve T cells are unable to import cystine due to the absence of cystine transporters, it has been suggested that T cell activation is dependent on cysteine generated by antigen presenting cells. The aim of this study was to determine at which phases during T cell activation exogenous cystine/cysteine is required and how T cells meet this requirement. We found that early activation of T cells is independent of exogenous cystine/cysteine, whereas T cell proliferation is strictly dependent of uptake of exogenous cystine/cysteine. Naïve T cells express no or very low levels of both cystine and cysteine transporters. However, we found that these transporters become strongly up-regulated during T cell activation and provide activated T cells with the required amount of cystine/cysteine needed for T cell proliferation. Thus, T cells are equipped with mechanisms that allow T cell activation and proliferation independently of cysteine generated by antigen presenting cells.
Trine Bøegh Levring; Ann Kathrine Hansen; Bodil Lisbeth Nielsen; Martin Kongsbak; Marina Rode von Essen; Anders Woetmann; Niels Odum; Charlotte Menné Bonefeld; Carsten Geisler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-14
Journal Detail:
Title:  Scientific reports     Volume:  2     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-22     Completed Date:  2013-04-12     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  266     Citation Subset:  IM    
Department of International Health, Immunology and Microbiology, University of Copenhagen, Blegdamsvej 3 , Copenhagen DK-2200, Denmark.
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MeSH Terms
CD4-Positive T-Lymphocytes / metabolism*
Cells, Cultured
Cysteine / metabolism*
Cystine / metabolism*
Lymphocyte Activation*
Membrane Transport Proteins / metabolism*
Polymerase Chain Reaction
Reg. No./Substance:
0/Membrane Transport Proteins; 52-90-4/Cysteine; 56-89-3/Cystine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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