Document Detail

Activated hepatic stellate cells participate in liver fibrosis in a patient with transfusional iron overload.
MedLine Citation:
PMID:  9773945     Owner:  NLM     Status:  MEDLINE    
We describe liver fibrosis caused by iron overload after a long history of blood transfusion in a patient with chronic renal failure. Pertinent laboratory data were: serum (s)-Fe 148 microg/dl; unsaturated iron binding capacity (UIBC) 14 microg/dl; s-ferritin 9350 ng/ml; human leukocyte antigen (HLA) A2, A24, B39, B55, Cw1, Cw7. Computed tomography revealed a high density in the liver, and laparoscopy revealed a brown liver. Liver histology showed bridging fibrosis from portal tracts. A heavy iron deposit was seen in Kupffer cells as well as in hepatocytes surrounded by fibrosis around the portal tracts. Immunocytochemistry revealed alpha-smooth muscle actin in many stellate cells distributed along the fibrotic area, and electron microscopy revealed infiltrating myofibroblastic stellate cells coexisting with collagen fibers around degenerated hepatocytes containing iron deposits. The findings are consistent with the notion that stellate cells play an important role in liver fibrogenesis in both genetic and transfusional iron overload hemochromatosis.
Y Harada; M Iwai; M Kakusui; T Mori; K Tada; Y Ishii; T Okanoue; K Kashima
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  33     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-15     Completed Date:  1998-12-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  751-4     Citation Subset:  IM    
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
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MeSH Terms
Blood Transfusion / adverse effects*
Diagnosis, Differential
Iron Overload / etiology*,  pathology
Liver / pathology*
Liver Cirrhosis / diagnosis*,  etiology*,  pathology

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