Document Detail

Activated THP-1 cells: an attractive model for the assessment of intracellular growth rates of Mycobacterium tuberculosis isolates.
MedLine Citation:
PMID:  14742569     Owner:  NLM     Status:  MEDLINE    
Capacity of certain Mycobacterium tuberculosis isolates to grow more rapidly in human macrophages may be indicative of increased virulence. Significant differences were observed in intracellular growth of two isolates from sites of tuberculosis transmission, with an outbreak-associated strain growing faster than a strain causing disease in only one person. Activated THP-1 cells are a suitable alternative to peripheral blood monocyte models.
S A Theus; M D Cave; K D Eisenach
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  72     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-02-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1169-73     Citation Subset:  IM    
Central Arkansas Veterans Healthcare System, Departments of Pathology, Microbiology-Immunology, and Anatomy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
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MeSH Terms
Cell Line, Tumor
Interferon-gamma / pharmacology
Leukemia, Monocytic, Acute / pathology
Macrophages / microbiology*
Mycobacterium tuberculosis / growth & development*
Tetradecanoylphorbol Acetate / pharmacology
Grant Support
Reg. No./Substance:
16561-29-8/Tetradecanoylphorbol Acetate; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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