| Actions of xylazine in young swine. | |
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MedLine Citation:
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PMID: 8989504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine sedative, analgesic, and basic cardiovascular effects of xylazine administered to pigs. ANIMALS: 6 two-month-old Landrace x Large White pigs. PROCEDURE: Xylazine was administered i.v. at increasing dosages (1, 2, 4, 8, and 16 mg/kg of body weight) to otherwise unmedicated, conscious pigs, and the aforementioned effects were determined before xylazine administration and 2, 5, 10, and 15 minutes later. Then a higher xylazine dosage was given after the 15-minute measurements were taken. RESULTS: None of the xylazine dosages induced sufficient analgesia to prevent painful response to tail clamping; considerable excitation with vocalization and without appreciable sedative effect was observed at all dosages. At lower dosages, cardiovascular effects were characterized by bradycardia and biphasic blood pressure response; initial hypertension was followed by hypotension. At higher dosages, severe hypotension with moderate bradycardia was followed by marked bradycardia and return to normal baseline values or slight increase in blood pressure. CONCLUSION: Xylazine did not induce adequate sedative or analgesic effects in pigs at any dosage tested; however, cardiovascular effects were considerable. These effects of xylazine differ from those observed in other domestic species. |
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Authors:
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I A Gómez de Segura; F J Tendillo; A Mascías; M Santos; J L Castillo-Olivares; E P Steffey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 58 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-01 Completed Date: 1997-04-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 99-102 Citation Subset: IM |
Affiliation:
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Departamento de Cirugía, Clínica Puerta de Hierro, Universidad Autónoma de Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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administration & dosage,
pharmacology* Anesthetics / administration & dosage, adverse effects, pharmacology* Animals Behavior, Animal / drug effects, physiology Blood Pressure / drug effects, physiology Bradycardia / chemically induced, physiopathology, veterinary Cardiovascular Physiological Phenomena Cardiovascular System / drug effects* Dose-Response Relationship, Drug Heart Rate / drug effects, physiology Hypertension / chemically induced, physiopathology, veterinary Hypnotics and Sedatives / administration & dosage, pharmacology* Injections, Intravenous Swine / physiology* Swine Diseases / chemically induced, physiopathology Time Factors Xylazine / administration & dosage, adverse effects, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anesthetics; 0/Hypnotics and Sedatives; 7361-61-7/Xylazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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