Document Detail


Actions of the uterine relaxant, fenoterol, on uteroplacental hemodynamics in human subjects.
MedLine Citation:
PMID:  952306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The action of fenoterol, a uterine relaxant of the adrenergic beta-mimetic group of drugs, has been investigated on placental, myometrial, and cardiac blood pools. 113mIndium was injected intravenously and the blood pools were measured by recording gamma activity externally. In eight cases with oxytocin-induced labor, fenoterol inhibited the typical blood pool changes of labor, i.e., contraction-synchronized decrease of placental and myometrial blood pools with increase in cardiac blood pool. Furthermore, fenoterol produced an increase in placental and myometrial pools with corresponding decrease of cardiac blood pool. These changes were observed consistently. In four other cases, of which three had spontaneous labor, similar effects were observed. The possible mechanisms of hemodynamic action of fenoterol, with reference to uterine relaxation, are discussed.
Authors:
T H Lippert; P B De Grandi; R Fridrich
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  125     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-10-02     Completed Date:  1976-10-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1093-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiac Output / drug effects
Chemical Phenomena
Chemistry
Ethanolamines / pharmacology*
Female
Fenoterol / pharmacology*
Hemodynamics / drug effects*
Humans
Labor, Induced
Myometrium / physiopathology
Oxytocin / pharmacology
Placenta
Pregnancy
Pregnancy Complications / physiopathology
Uterus
Chemical
Reg. No./Substance:
0/Ethanolamines; 13392-18-2/Fenoterol; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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