| Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans. | |
| | |
MedLine Citation:
|
PMID: 20100281 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Ghrelin is produced by enteroendocrine cells in the gastric mucosa and stimulates gastric emptying in healthy volunteers and patients with gastroparesis in short-term studies. The aim of this study was to evaluate effects of intravenous ghrelin on gastrointestinal motility and glucose homeostasis during a 6-h infusion in humans. METHODS: Ghrelin (15 pmol kg(-1) min(-1)) or saline was infused intravenously for 360 min after intake of radio-opaque markers, acetaminophen, and lactulose after a standardized breakfast in 12 male volunteers. Gastric emptying, orocecal transit, colonic transit, postprandial plasma concentrations of glucose, insulin, glucagon-like peptide-1 (GLP-1), and peptide YY were assessed. In vitro studies of gastrointestinal muscle contractility were performed. KEY RESULTS: The gastric emptying rate was faster for ghrelin compared to saline (P = 0.002) with a shorter half-emptying time (50.3 +/- 3.9 vs 59.9 +/- 4.4 min, P = 0.004). There was no effect of ghrelin on orocecal or colonic transit. Postprandial elevations of plasma glucose, insulin, and GLP-1 occurred 15 min earlier and were higher with ghrelin. The insulinogenic index did not change during ghrelin infusion. Basal in vitro contractility was unaffected by ghrelin. CONCLUSIONS & INFERENCES: The effect of a 6-h ghrelin infusion on gastrointestinal motility is limited to the stomach without affecting orocecal or colonic transit. Plasma glucose, insulin, and GLP-1 are elevated postprandially, probably as a result of the hastened gastric emptying. Changes in glucose homeostasis as a consequence of stimulated gastric emptying and hormone release, need to be taken into account in the use of pharmacological stimulants for the treatment of motility disorders. |
| | |
Authors:
|
Y Falkén; P M Hellström; G J Sanger; O Dewit; G Dukes; P Grybäck; J J Holst; E Näslund |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-01-21 |
Journal Detail:
|
Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 22 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-17 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
|
Languages: eng Pagination: e192-200 Citation Subset: IM |
Affiliation:
|
Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, SE-182 88 Stockholm, Sweden. ylva.falken@ds.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Appetite / drug effects Cecum / drug effects, physiology Colon / drug effects, physiology Double-Blind Method Energy Metabolism / drug effects Gastric Emptying Gastrointestinal Tract / drug effects Gastrointestinal Transit / drug effects* Ghrelin / administration & dosage, pharmacology* Glucagon-Like Peptide 1 / metabolism Glucose / metabolism* Homeostasis / drug effects Humans Hunger / drug effects Infusions, Intravenous Insulin / metabolism Male Muscle Contraction / drug effects Muscle, Smooth / drug effects Satiety Response / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Ghrelin; 11061-68-0/Insulin; 50-99-7/Glucose; 89750-14-1/Glucagon-Like Peptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain.
Next Document: Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is ...