| Actions and interactions of dihydropyridines and ethanol on the rat sinus node. | |
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MedLine Citation:
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PMID: 2484854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The actions and interactions of dihydropyridines (DHPs) and ethanol on sinus node (SN) automaticity were studied using rat sinoatrial preparations superfused with Tyrode's solution at 37 degrees C. Intracellular microelectrodes were used to monitor SN rate (SNR). The automaticity of the SN was not affected by nimodipine 10(-10) M, but it was depressed by a higher concentration of this calcium antagonist (10(-8) M). The racemic compound (+/-)Bay K 8644 had a dose-dependent biphasic chronotropic action: At 10(-8) M it decreased the SNR, while at 10(-7) M it increased the SNR. The negative component was blocked by atropine. A small concentration of ethanol (1.8 x 10(-2) M) had a positive chronotropic effect on the SN, and this action was blocked by nimodipine 10(-10) M. This small concentration of ethanol did not modify the chronotropic effects of either of the DHPs. A higher concentration of ethanol (5.3 x 10(-2) M) did not by itself affect the SNR, but it antagonized the chronotropic actions of the two DHPs. |
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Authors:
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P P Salvatici; O R Carryl; R L Isaacson; R G Carpentier |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 3 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1991-03-28 Completed Date: 1991-03-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 177-82 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC 20059. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
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pharmacology Animals Atropine / pharmacology Dihydropyridines / pharmacology* Drug Interactions Ethanol / pharmacology* Male Microelectrodes Myocardial Contraction / drug effects Nimodipine / pharmacology Rats Rats, Inbred Strains Sinoatrial Node / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Dihydropyridines; 51-55-8/Atropine; 64-17-5/Ethanol; 66085-59-4/Nimodipine; 71145-03-4/3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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