Document Detail


Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings.
MedLine Citation:
PMID:  1338897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ginsenoside Rb1 has previously been reported to improve memory deficits induced by anticholinergic drug treatment, and to facilitate acetylcholine (Ach) release from rat brain hippocampal slices. The increase in ACh release was not associated with an increase in calcium uptake into nerve terminals, but was associated with an increase in uptake of the precursor choline. In the present studies, analysis of choline uptake kinetics indicated that Rb1 increased the maximum velocity of choline uptake, while the affinity of the choline uptake carrier for choline (Km) was not significantly altered. Acute treatment with Rb1 did not alter the number of [3H]hemicholinium-3 (HC-3) binding sites in any of three cholinergic brain regions examined, suggesting that the increase in the maximum velocity of choline uptake was not associated with an increase in the number of choline carriers. However, chronic (3 day) administration of Rb1 did increase the number of choline uptake sites in the hippocampus, and to a lesser extent in the cortex.
Authors:
C G Benishin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemistry international     Volume:  21     ISSN:  0197-0186     ISO Abbreviation:  Neurochem. Int.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1993-06-24     Completed Date:  1993-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Medicine, University of Alberta, Edmonton, Canada.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism
Animals
Binding Sites
Biological Transport / drug effects
Brain / metabolism*
Carrier Proteins*
Cerebral Cortex / drug effects,  metabolism
Choline / metabolism*
Corpus Striatum / drug effects,  metabolism
Ginsenosides
Hemicholinium 3 / metabolism
Hippocampus / drug effects,  metabolism
Kinetics
Nerve Endings / drug effects,  metabolism*
Organ Specificity
Panax*
Plants, Medicinal*
Rats
Receptors, Cell Surface / metabolism
Saponins / pharmacology*
Synaptosomes / drug effects,  metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Ginsenosides; 0/Receptors, Cell Surface; 0/Saponins; 312-45-8/Hemicholinium 3; 51-84-3/Acetylcholine; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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