Document Detail

Actions of bile salts and of papaverine and intracellular cyclic AMP in isolated rat uterus.
MedLine Citation:
PMID:  238863     Owner:  NLM     Status:  MEDLINE    
Both antioxytocin and antiphosphodiesterase activities of desoxycholate were potentiated by lowering the pH of the medium. The results suggest the possibility that it is the bile salt in the non-ionized form which exerts the antioxytocin and antiphosphodiesterase action. The concentration of tissue cyclic AMP was measured at different times during relaxation of the uterus. The results show a significant increase in tissue cyclic AMP concentration at a time when the muscle was just beginning to relax in response to papaverine, but not in response to chenodesoxycholate. The intracellular level of cyclic AMP during relaxation of the uterus produced by papaverine or chenodesoxycholate was, however, significantly increased when relaxation was about 90% complete. The difference between the mode of action of papaverine and that of the bile salts is discussed.
T Uruno; I Takayanagi; K Kubota; K Takagi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  32     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-11-06     Completed Date:  1975-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  116-9     Citation Subset:  IM    
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MeSH Terms
Bile Acids and Salts / pharmacology*
Chenodeoxycholic Acid / pharmacology
Cyclic AMP / pharmacology*
Deoxycholic Acid / pharmacology
Hydrogen-Ion Concentration
Ovary / physiology
Papaverine / pharmacology*
Phosphodiesterase Inhibitors
Time Factors
Uterus / drug effects*,  enzymology
Reg. No./Substance:
0/Bile Acids and Salts; 0/Phosphodiesterase Inhibitors; 474-25-9/Chenodeoxycholic Acid; 58-74-2/Papaverine; 60-92-4/Cyclic AMP; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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