| Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly? | |
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MedLine Citation:
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PMID: 19018562 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aldosterone and its receptor, the mineralocorticoid receptor (MR), play a key role in the regulation of reno-cardiovascular function as well as in the regulation of normal and abnormal reno-cardiovascular function, which are responsible for the variety of its functional responses. The underlying mechanisms are of genomic and nongenotropic nature. Prevention of critical arterial hypotension by NaCl retention and regulation of potassium homeostasis, which is of eminent importance for cardiovascular electrophysiology and rhythmogenesis, represent the good face of aldosterone in the cardiovascular system. Triggering of persistent arterial hypertension with all the detrimental secondary effects on heart, kidney, vessels, and brain represents the bad face of aldosterone/MR in the cardiovascular system. Blood pressure-independent reno-cardiovascular end organ damage represents the ugly face of MR activation and does not depend on elevated aldosterone concentrations. In this way, aldosterone/MR induces or facilitates inflammatory and fibrotic processes in a permissive milieu, created for example by angiotensin II or NaCl and characterized by enhanced oxidative stress, in vascular walls. |
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Authors:
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Michael Gekle; Claudia Grossmann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-19 |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 458 ISSN: 1432-2013 ISO Abbreviation: Pflugers Arch. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-13 Completed Date: 2009-08-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 231-46 Citation Subset: IM |
Affiliation:
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Julius-Bernstein-Institut für Physiologie, Universität Halle-Wittenberg, Magdeburger Strasse 6, 06097 Halle (Saale), Germany. michael.gekle@medizin.uni-halle.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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physiology* Angiotensin II / physiology Blood Pressure / drug effects, physiology Cardiovascular System / drug effects*, metabolism* Homeostasis / drug effects Hypertension / etiology Inflammation / etiology Receptor, Epidermal Growth Factor / physiology Receptors, Aldosterone / physiology Signal Transduction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Aldosterone; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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