Document Detail

Action of steroids on H+ and NH+4 excretion in the toad urinary bladder.
MedLine Citation:
PMID:  113550     Owner:  NLM     Status:  MEDLINE    
This study was done to determine if steroid compounds will stimulate the urinary bladder of the toad to increase its capacity to acidify the urine and excrete NH+4. Aldosterone, 17 beta-estradiol, dexamethasone, pregnenolone, and cholesterol were tested on the bladder. All compounds tested were found to stimulate the rate of acidification by the bladder, above that of a paired control hemibladder. In contrast, only the steroids aldosterone and 17 beta-estradiol were found to stimulate NH+4 excretion in the bladder. Cycloheximide was found to block the action of aldosterone on the NH+4 excretion, but did not have a significant effect on the stimulation of acidification by aldosterone. We conclude that steroids stimulate H+ and NH+4 excretion in the toad urinary bladder. In addition, the NH+4 excretory system seems to be more specific to this effect than is the H+ excretory system.
L W Frazier; N Y Zachariah
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of membrane biology     Volume:  49     ISSN:  0022-2631     ISO Abbreviation:  J. Membr. Biol.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0211301     Medline TA:  J Membr Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-308     Citation Subset:  IM    
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MeSH Terms
Aldosterone / pharmacology
Bufo marinus
Cholesterol / pharmacology
Dexamethasone / pharmacology
Dose-Response Relationship, Drug
Estradiol / pharmacology
Hydrogen / metabolism*
Mineralocorticoids / pharmacology*
Pregnenolone / pharmacology
Quaternary Ammonium Compounds / metabolism*
Sodium / metabolism
Urinary Bladder / drug effects*,  metabolism
Reg. No./Substance:
0/Mineralocorticoids; 0/Quaternary Ammonium Compounds; 1333-74-0/Hydrogen; 145-13-1/Pregnenolone; 50-02-2/Dexamethasone; 50-28-2/Estradiol; 52-39-1/Aldosterone; 57-88-5/Cholesterol; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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