Document Detail

Action of staphylococcal epidermolytic toxin on mouse skin: an electron microscopic study.
MedLine Citation:
PMID:  1081558     Owner:  NLM     Status:  MEDLINE    
The ultrastructure of the skin of 3-day-old mice challenged with small doses of highly purified staphylococcal epidermolytic toxin was examined at various time intervals. Up to 130 min few changes were evident, but at this time wide gaps developed between cells in the horizontal planes of the stratum granulosum, and "bubbles" normally present in the intracellular spece were no longer apparent. Splitting of the desmosomes occurred after the development of distended intercellular spaces. After 20 hr, that is, in the "healing" phase, the appearance suggested that normal maturation of keratinocytes was altered. Also at this time a degree of cell separation was still apparent in the outermost actively maturing layer of the stratum granulosum. The proteinase inhibitor Trasylol was tested for its effect on the toxin when administered up to 45 min after challenge.
A L McLay; J P Arbuthnott; A Lyell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  65     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-09     Completed Date:  1976-02-09     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  423-8     Citation Subset:  AIM; IM    
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MeSH Terms
Antitoxins / therapeutic use
Aprotinin / therapeutic use
Epidermal Necrolysis, Toxic / pathology*
Protease Inhibitors
Skin / pathology,  ultrastructure*
Skin Diseases, Infectious / drug therapy,  etiology,  pathology*
Staphylococcal Infections / drug therapy,  etiology,  pathology*
Staphylococcus aureus
Toxins, Biological
Reg. No./Substance:
0/Antitoxins; 0/Protease Inhibitors; 0/Toxins, Biological; 9087-70-1/Aprotinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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